Description

3-Fluoroaniline (CAS No. 372-19-0) is a high-purity aromatic amine derivative with the molecular formula C₆H₆FN, widely utilized in pharmaceutical, agrochemical, and materials science research. This compound, also known as m-Fluoroaniline or 1-Amino-3-fluorobenzene, features a fluorine substituent at the meta position of the aniline ring, offering unique electronic and steric properties for synthetic applications. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed packaging under inert conditions to prevent degradation. Ideal for use as a building block in nucleophilic substitution reactions, cross-coupling reactions, and as a precursor for fluorinated heterocycles. Available in quantities ranging from grams to multi-kilogram scales with customizable packaging options.

Properties

• CAS Number: 372-19-0
• Complexity: 74.9
• IUPAC Name: 3-fluoroaniline
• InChI: InChI=1S/C6H6FN/c7-5-2-1-3-6(8)4-5/h1-4H,8H2
• InChI Key: QZVQQUVWFIZUBQ-UHFFFAOYSA-N
• Exact Mass: 111.048427358
• Molecular Formula: C6H6FN
• Molecular Weight: 111.12
• SMILES: C1=CC(=CC(=C1)F)N
• Topological: 26
• Monoisotopic Mass: 111.048427358
• Synonyms: 3-FLUOROANILINE, 372-19-0, m-Fluoroaniline, 1-Amino-3-fluorobenzene, Benzenamine, 3-fluoro-, 3-Fluoranilin, Aniline, 3-fluoro-, 3-Fluorobenzenamine, 3-Fluoro-phenylamine, Aniline, m-fluoro-, 3-Fluoranilin [Czech], m-fluorophenylamine, m-aminofluorobenzene, NSC 10300, TLL4X88AZP, EINECS 206-747-0, BRN 1305471, CHEBI:27873, AI3-28559, NSC-10300, 4-AMINO-2-FLUOROBENZENE, DTXSID10190683, 4-12-00-01101 (Beilstein Handbook Reference), Aniline, m-fluoro-(8CI), DTXCID50113174, 206-747-0, inchi=1/c6h6fn/c7-5-2-1-3-6(8)4-5/h1-4h,8h, qzvqquvwfizubq-uhfffaoysa-n, 3-fluorophenylamine, MFCD00007758, 3-flouroaniline, 5-fluoroaniline, 3-fluoraniline, meta-fluoroaniline, 3-fluoro aniline, 3-fluoro-aniline, m-Fluoro phenylamine, 3-fluorophenyl amine, 3-fluorobenzenaminium, 1,3-fluorobenzenamine, 3-Fluoroaniline, 99%, UNII-TLL4X88AZP, WLN: ZR CF, SCHEMBL33929, SCHEMBL69208, CHEMBL58888, SCHEMBL197429, SCHEMBL468092, SCHEMBL1029420, SCHEMBL1528719, BCP13758, NSC10300, SBB059856, STL164342, AKOS000119146, CS-W020419, PS-9262, DB-023953, F0101, NS00042187, ST51046120, 3-Fluoroaniline, technical, >=97.0% (GC), 3-Fluorobenzenamine; 1-Amino-3-fluorobenzene, EN300-19094, A19472, m-Fluoroaniline [UN2941] [Keep away from food], Q27103382, F2190-0426

Application

3-Fluoroaniline serves as a versatile intermediate in the synthesis of fluorinated pharmaceuticals, including kinase inhibitors and antimicrobial agents. Its electron-withdrawing fluorine group enhances reactivity in palladium-catalyzed cross-coupling reactions, such as Buchwald-Hartwig amination. In agrochemical research, it is employed to develop herbicides and pesticides with improved metabolic stability. Additionally, it is used in materials science to synthesize fluorinated polymers and liquid crystals.

Safety and Hazards

GHS Hazard Statements

• H301 (11.8%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (88.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (13.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (96.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (82.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (15.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (13.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (86.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (13.7%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (11.8%)
• Acute Tox. 4 (88.2%)
• Acute Tox. 4 (13.7%)
• Skin Irrit. 2 (96.1%)
• Eye Dam. 1 (82.4%)
• Eye Irrit. 2 (15.7%)
• Acute Tox. 4 (13.7%)
• STOT SE 3 (86.3%)
• STOT RE 2 (13.7%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.