Description

3-Fluoroacetophenone (CAS No. 455-36-7) is a high-purity fluorinated aromatic ketone with the molecular formula C₈H₇FO and IUPAC name 1-(3-fluorophenyl)ethanone. This compound is a valuable building block in organic synthesis, pharmaceutical research, and material science due to its reactive carbonyl group and fluorine substitution. It is supplied as a clear to pale-yellow liquid with a characteristic aromatic odor, ensuring optimal compatibility for nucleophilic additions, reductions, and other key transformations. Ideal for researchers and industrial chemists, our 3-Fluoroacetophenone is rigorously tested for purity (typically ≥98% by GC) and stability, packaged under inert conditions to prevent degradation. Suitable for use in HPLC, NMR, and advanced synthetic applications.

Properties

• CAS Number: 455-36-7
• Complexity: 133
• IUPAC Name: 1-(3-fluorophenyl)ethanone
• InChI: InChI=1S/C8H7FO/c1-6(10)7-3-2-4-8(9)5-7/h2-5H,1H3
• InChI Key: HCEKGPAHZCYRBZ-UHFFFAOYSA-N
• Exact Mass: 138.048093005
• Molecular Formula: C8H7FO
• Molecular Weight: 138.14
• SMILES: CC(=O)C1=CC(=CC=C1)F
• Topological: 17.1
• Monoisotopic Mass: 138.048093005
• Synonyms: 3′-Fluoroacetophenone, 3-FLUOROACETOPHENONE, EINECS 207-245-4, NSC 88301, 207-245-4, 455-36-7, 1-(3-Fluorophenyl)ethanone, m-Fluoroacetophenone, 1-(3-fluorophenyl)ethan-1-one, Ethanone, 1-(3-fluorophenyl)-, 1-acetyl-3-fluorobenzene, 3/’-Fluoroacetophenone, Acetophenone, 3′-fluoro-, MFCD00000338, NSC-88301, Ethanone, 1-[3-fluorophenyl]-, NSC88301, m-fluoro acetophenone, 3′-fluoro-acetophenone, 3′-Fluoroacetophenone, ETU68KSP9P, NCIOpen2_001445, SCHEMBL69483, 3′-Fluoroacetophenone, 99%, SCHEMBL194972, 1-(3-fluoro-phenyl)-ethanone, 1-(3-Fluorophenyl)ethanone #, SCHEMBL3391247, DTXSID8073186, SCHEMBL17256645, SCHEMBL21179316, CS-D1392, SBB063564, STL195585, AKOS000119793, AC-3640, FA54804, PS-9092, SY007259, 3′-Fluoroacetophenone;m-Fluoroacetophenone, DB-010012, F0262, NS00044052, EN300-18195, 3 inverted exclamation mark -Fluoroacetophenone, F0001-1232, Z256709632, InChI=1/C8H7FO/c1-6(10)7-3-2-4-8(9)5-7/h2-5H,1H

Application

3-Fluoroacetophenone is widely used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty materials. Its fluorine moiety enhances bioavailability and metabolic stability in drug development, making it valuable for medicinal chemistry. The compound is also employed in the preparation of liquid crystals and advanced polymers. Researchers utilize it in cross-coupling reactions and as a precursor for fluorinated heterocycles.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.