Description

Description

[3-Fluoro-5-(trifluoromethyl)phenyl]methanol (CAS No. 184970-29-4) is a high-purity fluorinated aromatic alcohol with the molecular formula C₈H₆F₄O. This compound features a benzyl alcohol moiety substituted with both fluorine and trifluoromethyl groups at the 3- and 5-positions, respectively, making it a valuable intermediate in synthetic organic chemistry and pharmaceutical research. Its unique electronic and steric properties enhance reactivity in cross-coupling reactions, nucleophilic substitutions, and as a precursor for advanced fluorinated materials. Supplied as a clear to pale-yellow liquid or low-melting solid, it is rigorously tested for purity (typically ??95% by GC or HPLC) and stored under inert conditions to ensure stability. Ideal for researchers developing novel agrochemicals, pharmaceuticals, or liquid crystals requiring fluorinated building blocks.

Application

[3-Fluoro-5-(trifluoromethyl)phenyl]methanol serves as a versatile synthon in medicinal chemistry for introducing fluorinated phenyl motifs into drug candidates, enhancing metabolic stability and bioavailability. It is employed in Suzuki-Miyaura couplings to create biaryl structures for kinase inhibitors or PET radiotracers. The trifluoromethyl group also facilitates applications in agrochemical synthesis, particularly for herbicides and fungicides with improved lipophilicity.

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