Description

3-Fluoro-5-nitropyridin-2-OL (CAS No. 1033202-14-0) is a high-purity fluorinated nitropyridine derivative with the molecular formula C₅H₃FN₂O₃. This compound, also known by its IUPAC name 3-fluoro-5-nitro-1H-pyridin-2-one, is a versatile heterocyclic building block widely used in pharmaceutical and agrochemical research. The presence of both fluoro and nitro substituents on the pyridine ring enhances its reactivity, making it valuable for nucleophilic aromatic substitution reactions and as a precursor for more complex molecules.

Our product is synthesized under stringent quality control measures to ensure ≥95% purity (HPLC) and is supplied as a fine, crystalline powder. Each batch undergoes rigorous analytical characterization, including ¹H NMR, ¹³C NMR, and LC-MS to verify identity and purity. Suitable for medicinal chemistry, material science, and chemical biology applications, this compound is packaged under inert atmosphere to ensure long-term stability.

Key Features:

• CAS: 1033202-14-0
• Molecular Weight: 158.09 g/mol
• Exact Mass: 158.0127 (monoisotopic)
• Storage: Store at 2-8°C in a dry environment
• Hazard Codes: Xi (Irritant)

Properties

• CAS Number: 1033202-14-0
• Complexity: 276
• IUPAC Name: 3-fluoro-5-nitro-1H-pyridin-2-one
• InChI: InChI=1S/C5H3FN2O3/c6-4-1-3(8(10)11)2-7-5(4)9/h1-2H,(H,7,9)
• InChI Key: WKCYGBXTZFFWMY-UHFFFAOYSA-N
• Exact Mass: 158.01277012
• Molecular Formula: C5H3FN2O3
• Molecular Weight: 158.09
• SMILES: C1=C(C(=O)NC=C1[N+](=O)[O-])F
• Topological: 74.9
• Monoisotopic Mass: 158.01277012
• Synonyms: 3-FLUORO-5-NITROPYRIDIN-2-OL, 1033202-14-0, 3-Fluoro-5-nitropyridin-2(1H)-one, 3-fluoro-5-nitro-1H-pyridin-2-one, 3-FLUORO-2-HYDROXY-5-NITROPYRIDINE, MFCD10699675, SCHEMBL14659678, SCHEMBL28651135, DTXSID80674485, WKCYGBXTZFFWMY-UHFFFAOYSA-N, 3-Fluoro-5-nitro-2(1H)-pyridinone, AKOS006303206, AB62596, BS-26075, SY205245, DB-424981, CS-0088246, EN300-248933

Application

3-Fluoro-5-nitropyridin-2-OL serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly kinase inhibitors and antibacterial agents. The electron-withdrawing nitro group facilitates subsequent reduction to amino derivatives for further functionalization. Researchers utilize this compound in Suzuki-Miyaura coupling reactions to create biaryl structures common in drug discovery. Its unique substitution pattern also makes it valuable for developing novel materials with tailored electronic properties.

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