Description

3-Fluoro-5-methylaniline (CAS No. 52215-41-5) is a high-purity fluorinated aromatic amine with the molecular formula C₇H₈FN. This specialized organic compound features a fluorine substituent at the 3-position and a methyl group at the 5-position of the aniline ring, offering unique electronic and steric properties for advanced synthetic applications. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied as a clear to pale yellow liquid with careful handling recommendations due to its amine functionality. Ideal for pharmaceutical intermediates, agrochemical research, and materials science, this building block is packaged under inert gas in amber glass bottles to ensure stability. Technical data including ¹H/¹³C NMR spectra and MSDS are available upon request.

Properties

• CAS Number: 52215-41-5
• Complexity: 94.9
• IUPAC Name: 3-fluoro-5-methyl-aniline
• InChI: InChI=1S/C7H8FN/c1-5-2-6(8)4-7(9)3-5/h2-4H,9H2,1H3
• InChI Key: DPHBKGYVIHTBDG-UHFFFAOYSA-N
• Exact Mass: 125.064077422
• Molecular Formula: C7H8FN
• Molecular Weight: 125.14
• SMILES: CC1=CC(=CC(=C1)F)N
• Topological: 26
• Monoisotopic Mass: 125.064077422
• Synonyms: 3-Fluoro-5-methylaniline, 52215-41-5, DTXSID70380947, DTXCID50331972, 810-590-9, 3-Amino-5-fluorotoluene, MFCD00077538, 3-fluoranyl-5-methyl-aniline, Benzenamine, 3-fluoro-5-methyl-, 3-fluoro-5-methyl-aniline, 3-Fluoro-5-aminotoluene, 5-Methyl-3-fluoroaniline, 3-fluoro-5-methylbenzenamine, 5-fluoro-3-methylphenylamine, SCHEMBL458376, DPHBKGYVIHTBDG-UHFFFAOYSA-N, SBB069824, AKOS006230230, AC-2612, CS-W002331, DS-0889, PS-9195, SY019381, DB-006447, EN300-50153, A811634, A828986

Application

3-Fluoro-5-methylaniline serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of kinase inhibitors and CNS-active compounds. The electron-withdrawing fluorine and electron-donating methyl groups enable precise tuning of electronic properties in drug discovery. This compound is also utilized in agrochemical research for creating novel pesticides with enhanced bioavailability. Additionally, it finds application in materials science as a precursor for fluorinated polyanilines and specialty dyes.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (50%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.