Description

3-Fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS No. 819057-45-9) is a high-purity boronic ester derivative with the molecular formula C₁₂H₁₇BFNO₂. This compound features a reactive pinacol boronate group and an aniline moiety, making it a versatile intermediate for Suzuki-Miyaura cross-coupling reactions and other organoboron chemistry applications. Its stable tetramethyl dioxaborolane ring ensures excellent shelf-life and handling properties under inert conditions. Ideal for pharmaceutical research, materials science, and agrochemical development, this reagent is supplied as a crystalline solid with ≥95% purity (HPLC). Store under nitrogen at 2-8°C to maintain stability. Suitable for use in controlled environments by trained professionals.

Properties

• CAS Number: 819057-45-9
• Complexity: 282
• IUPAC Name: 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
• InChI: InChI=1S/C12H17BFNO2/c1-11(2)12(3,4)17-13(16-11)9-6-5-8(15)7-10(9)14/h5-7H,15H2,1-4H3
• InChI Key: FLMNWVXAEGUVNY-UHFFFAOYSA-N
• Exact Mass: 237.1336371
• Molecular Formula: C12H17BFNO2
• Molecular Weight: 237.08
• SMILES: B1(OC(C(O1)(C)C)(C)C)C2=C(C=C(C=C2)N)F
• Topological: 44.5
• Monoisotopic Mass: 237.1336371
• Synonyms: 3-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, 690-890-2, 819057-45-9, 4-AMINO-2-FLUOROPHENYLBORONIC ACID PINACOL ESTER, 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, MFCD09951877, 4-Amino-2-fluorophenylboronic acid, pinacol ester, FLMNWVXAEGUVNY-UHFFFAOYSA-N, BENZENAMINE, 3-FLUORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-, SCHEMBL60187, 4-AMINO-2-FLUOROBENZENEBORONIC ACID PINACOL ESTER, SCHEMBL28607848, (4-AMINO-2-FLUOROPHENYL)BORONIC ACID PINACOL ESTER, DTXSID30660651, SBB098728, AKOS015960167, CS-W005873, MB08227, NCGC00662597-01, DS-17106, SY007761, 4-Amino-2-fluorophenylboronic acid picol ester, EN300-115267, 4-Amino-2-fluorobenzene boronic acid pinacol ester, 4-amino-2-fluorophenyl boronic acid pinacol ester, Z1483425423, 4-Amino-2-fluorophenylboronic acid pinacol ester, AldrichCPR, 3-fluoro-4-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))phenylamine, 3-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine, 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-aniline, 4-aMino-2-fluorophenylboronic acid pinacol ester, 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Application

3-Fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is widely used as a key building block in palladium-catalyzed cross-coupling reactions to synthesize fluorinated biaryl compounds. It serves as a precursor for pharmaceutical intermediates, particularly in the development of kinase inhibitors and PET radiotracers. The compound’s boronate ester group also enables its use in polymer chemistry and functional material design.

Safety and Hazards

GHS Hazard Statements

• H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (25%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.