Description

3-Fluoro-4-methoxyaniline (CAS No. 366-99-4) is a high-purity aromatic amine derivative with the molecular formula C₇H₈FNO. This compound features a fluorine substituent at the 3-position and a methoxy group at the 4-position of the aniline ring, making it a versatile intermediate for organic synthesis and pharmaceutical research. Its well-defined structure (IUPAC name: 3-fluoro-4-methoxyaniline) ensures consistent reactivity in electrophilic substitution and coupling reactions. Ideal for researchers, this product is rigorously tested for purity and stability, supplied in sealed packaging to prevent degradation. Suitable for use in drug discovery, agrochemical development, and advanced material science applications.

Properties

• CAS Number: 366-99-4
• Complexity: 110
• IUPAC Name: 3-fluoro-4-methoxy-aniline
• InChI: InChI=1S/C7H8FNO/c1-10-7-3-2-5(9)4-6(7)8/h2-4H,9H2,1H3
• InChI Key: LJWAPDSCYTZUJU-UHFFFAOYSA-N
• Exact Mass: 141.058992041
• Molecular Formula: C7H8FNO
• Molecular Weight: 141.14
• SMILES: COC1=C(C=C(C=C1)N)F
• Topological: 35.3
• Monoisotopic Mass: 141.058992041
• Synonyms: 3-Fluoro-4-methoxyaniline, 366-99-4, DTXSID30342364, DTXCID90293444, 627-615-2, 3-fluoro-4-anisidine, 3-Fluoro-p-anisidine, 4-Amino-2-fluoroanisole, BENZENAMINE, 3-FLUORO-4-METHOXY-, MFCD00075040, 3-fluoro-4-methoxyphenylamine, 3-FLUORO-4-METHOXY-PHENYLAMINE, 3-fluoro-4-methoxy-aniline, 4-Amino-2-fluoro-1-methoxybenzene, 4-amino-2-fluoroanisol, 3-fluoro-4-methoxy aniline, 4-methoxy-3-fluoro-aniline, SCHEMBL76201, 3-Fluoro-4-methoxyaniline #, 3-fluoro-4-methoxybenzenamine, 3-Fluoro-p-anisidine, 98%, SCHEMBL366022, SCHEMBL25181953, BCP05898, BBL100259, SBB028264, STL169014, AKOS005064092, AC-3682, CS-W008832, FF64342, PS-9016, SB75433, SY020880, DB-006439, F0648, ST50823730, EN300-41272, A19764, F5608-0077, Z362635046, 71B

Application

3-Fluoro-4-methoxyaniline serves as a key building block in the synthesis of pharmaceuticals, particularly for the development of fluorinated bioactive molecules. Its electron-rich aromatic ring facilitates the creation of heterocyclic compounds and ligands for catalysis. Researchers also utilize it in the preparation of dyes, pigments, and advanced polymers due to its reactive amine group. The fluorine moiety enhances metabolic stability in drug candidates, making it valuable for medicinal chemistry.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (95.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (95.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (95.7%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (95.7%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.