Description

3-Chloro-p-anisic acid (CAS No. 37908-96-6), also known as 3-chloro-4-methoxybenzoic acid, is a high-purity organic compound with the molecular formula C₈H₇ClO₃. This white to off-white crystalline powder is a versatile intermediate in pharmaceutical, agrochemical, and specialty chemical synthesis. With a molecular weight of 186.59 g/mol, it features a chloro-substituted aromatic ring with a methoxy group at the para position relative to the carboxylic acid functionality. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied with full analytical documentation including ¹H NMR, FT-IR, and GC/MS data. Suitable for research scale applications, this compound is packaged under inert atmosphere in amber glass vials with PTFE-lined caps to ensure stability. Storage recommendation: 2-8°C in a dry environment.

Properties

• CAS Number: 37908-96-6
• Complexity: 172
• IUPAC Name: 3-chloro-4-methoxy-benzoic acid
• InChI: InChI=1S/C8H7ClO3/c1-12-7-3-2-5(8(10)11)4-6(7)9/h2-4H,1H3,(H,10,11)
• InChI Key: IBCQUQXCTOPJOD-UHFFFAOYSA-N
• Exact Mass: 186.0083718
• Molecular Formula: C8H7ClO3
• Molecular Weight: 186.59
• SMILES: COC1=C(C=C(C=C1)C(=O)O)Cl
• Topological: 46.5
• Monoisotopic Mass: 186.0083718
• Synonyms: 3-Chloro-4-methoxybenzoic acid, 37908-96-6, 3-Chloro-p-anisic acid, EINECS 253-708-9, DTXSID20191343, DTXCID30113834, 253-708-9, Benzoic acid, 3-chloro-4-methoxy-, MFCD00016512, XE349DXL4Q, Benzoic acid, 3-?chloro-?4-?methoxy-, 3-Chloro-4-methoxybenzolic acid, 3-Chloro-4-methoxybenzoicAcid, UNII-XE349DXL4Q, SCHEMBL308170, 3-chloro-4-methoxy benzoic acid, BBL002734, SBB019257, STK520303, AKOS000288890, 3-Chloro-4-methoxybenzoic acid, 97%, CS-W016880, FC37634, FS-1527, SY018640, DB-031119, ST4147495, C2550, NS00030310, EN300-18284, I11253, AE-848/06129035, Z57790676

Application

3-Chloro-p-anisic acid serves as a key building block in medicinal chemistry for the synthesis of bioactive molecules, particularly non-steroidal anti-inflammatory drug (NSAID) analogs. In material science, it finds use as a precursor for liquid crystal monomers due to its rigid aromatic structure and polar substituents. The compound’s dual functionality (acid and ether groups) makes it valuable for designing novel polymer additives and coordination complexes in catalyst development.

Safety and Hazards

GHS Hazard Statements

• H301 (87%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (13%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (15.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (10.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H400 (87%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (87%)
• Skin Irrit. 2 (13%)
• Eye Irrit. 2A (15.2%)
• STOT SE 3 (10.9%)
• Aquatic Acute 1 (87%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.