Description

3-Chloro-5-(trifluoromethyl)aniline (CAS No. 69411-05-8) is a high-purity aromatic amine derivative with the molecular formula C₇H₅ClF₃N. This compound features a chloro-substituted phenyl ring and a trifluoromethyl group, making it a versatile intermediate for pharmaceutical, agrochemical, and specialty chemical synthesis. Its IUPAC name is 3-chloro-5-(trifluoromethyl)aniline, and it is supplied as a crystalline solid with exceptional stability under recommended storage conditions. Ideal for researchers and industrial scientists, this reagent is rigorously tested for purity (typically ≥97% by GC or HPLC) and is available in scalable quantities. Suitable for use in cross-coupling reactions, amidation, and as a building block for advanced heterocyclic compounds.

Properties

• CAS Number: 69411-05-8
• Complexity: 159
• IUPAC Name: 3-chloro-5-(trifluoromethyl)aniline
• InChI: InChI=1S/C7H5ClF3N/c8-5-1-4(7(9,10)11)2-6(12)3-5/h1-3H,12H2
• InChI Key: OVENUGPMQDFGLE-UHFFFAOYSA-N
• Exact Mass: 195.0062613
• Molecular Formula: C7H5ClF3N
• Molecular Weight: 195.57
• SMILES: C1=C(C=C(C=C1N)Cl)C(F)(F)F
• Topological: 26
• Monoisotopic Mass: 195.0062613
• Synonyms: 69411-05-8, 3-Chloro-5-(trifluoromethyl)aniline, EINECS 273-989-1, DTXSID50989250, DTXCID501416376, 273-989-1, 3-chloro-5-trifluoromethylaniline, 3-Amino-5-chlorobenzotrifluoride, 3-Amino-5-chlorobenzotrifloride, MFCD02684210, Benzenamine, 3-chloro-5-(trifluoromethyl)-, 5-amino-3chlorobenzotrifluoride, SCHEMBL1012745, 5-amino-3chloro-benzotrifluoride, 5-amino-3-chloro-benzotrifluoride, 3-Chloro-5-trifluoromethyl-aniline, CL8424, SBB091923, AKOS006343925, CS-W015716, 5-chloro-3-(trifluoromethyl)phenylamine, AC-11534, AS-18505, SY033056, NS00061922, EN300-133139

Application

3-Chloro-5-(trifluoromethyl)aniline is widely used as a key intermediate in the synthesis of pharmaceuticals, particularly for bioactive molecules targeting CNS disorders and antimicrobial agents. Its trifluoromethyl group enhances lipophilicity, making it valuable in agrochemical formulations such as herbicides and fungicides. Researchers also employ it in material science for designing fluorinated polymers and liquid crystals.

Safety and Hazards

GHS Hazard Statements

• H302+H312+H332 (12.5%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (75%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (75%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (75%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (75%)
• Acute Tox. 4 (75%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (75%)
• STOT SE 3 (50%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.