Description

3-Chloro-5-fluorophenylboronic acid (CAS No. 328956-61-2) is a high-purity boronic acid derivative with the molecular formula C₆H₅BClFO₂. This organoboron compound is widely used in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern synthetic organic chemistry, due to its excellent reactivity and stability. The presence of both chloro and fluoro substituents on the phenyl ring enhances its utility in constructing complex aromatic systems for pharmaceuticals, agrochemicals, and materials science applications. Available as a white to off-white crystalline powder, our product is rigorously tested to ensure ≥95% purity (HPLC) and is packaged under inert conditions to prevent degradation. Ideal for researchers requiring precise control in C-C bond formation, this reagent is supplied with detailed analytical certificates (CoA) including ¹H NMR, ¹³C NMR, and LC-MS data.

Properties

• CAS Number: 328956-61-2
• Complexity: 136
• IUPAC Name: (3-chloro-5-fluoro-phenyl)boronic acid
• InChI: InChI=1S/C6H5BClFO2/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,10-11H
• InChI Key: XYQDHVBKUNNLGZ-UHFFFAOYSA-N
• Exact Mass: 174.0055154
• Molecular Formula: C6H5BClFO2
• Molecular Weight: 174.37
• SMILES: B(C1=CC(=CC(=C1)Cl)F)(O)O
• Topological: 40.5
• Monoisotopic Mass: 174.0055154
• Synonyms: 3-chloro-5-fluorophenylboronic acid, 328956-61-2, (3-chloro-5-fluorophenyl)boronic acid, 3-Chloro-5-fluorobenzeneboronic acid, MFCD06801741, 3-Chloro-5-fluorophenlyboronic acid, Boronic acid, (3-chloro-5-fluorophenyl)-, 3-Chloro-5-fluorophenylboronicacid, SCHEMBL5524, DTXSID00572313, XYQDHVBKUNNLGZ-UHFFFAOYSA-N, BBL100993, SBB071242, STL554787, 3-chloro-5-fluoro-benzeneboronic acid, AKOS004113767, AB30220, CS-W003356, GS-6553, SY014161, DB-010569, C2914, EN300-117486, Z1201623919, 3-Chloro-5-fluorobenzeneboronic Acid (contains varying amounts of Anhydride), 3-chloro-5-fluorophenylboronic acid (contains varying amounts of anhydride)

3-Chloro-5-fluorophenylboronic acid is primarily employed in palladium-catalyzed cross-coupling reactions to synthesize biaryl compounds for drug discovery. It serves as a key intermediate in the development of pharmaceutical candidates, particularly kinase inhibitors and antimicrobial agents. The compound’s halogenated aryl structure also makes it valuable in material science for creating functionalized polymers and liquid crystals. Handle under inert atmosphere to maintain stability.

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.