Description

Description

3-Chloro-5-fluorobenzonitrile (CAS No. 327056-73-5) is a high-purity aromatic nitrile compound with the molecular formula C₇H₃ClFN. This halogenated benzonitrile derivative is a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical research. The compound features both chloro and fluoro substituents on the benzene ring, offering unique electronic and steric properties for regioselective reactions. Its nitrile group serves as a reactive handle for further functionalization, including hydrolysis to carboxylic acids or reduction to primary amines. Supplied as a white to off-white crystalline solid, this reagent is characterized by excellent batch-to-batch consistency (>98% purity by HPLC) and is packaged under inert atmosphere to ensure long-term stability. Ideal for cross-coupling reactions, heterocycle synthesis, and medicinal chemistry applications.

Application

3-Chloro-5-fluorobenzonitrile serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and CNS-targeting compounds. Its halogen substituents enable efficient Suzuki-Miyaura and Buchwald-Hartwig coupling reactions in drug discovery. The compound is also employed in material science for developing liquid crystals and organic semiconductors. Researchers utilize its nitrile group for constructing pyrimidine and triazine heterocycles in agrochemical development.

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