Atomfair

Awaiting product image

Atomfair 3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine C11H15BClNO2 CAS 865186-94-3

3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS No. 865186-94-3) is a high-purity boronic ester derivative with the molecular formula C11H15BClNO2. This compound features a pyridine ring substituted with a chloro group at the 3-position and a pinacol boronate ester at the 5-position, making it a versatile intermediate for Suzuki-Miyaura cross-coupling reactions. Its stable dioxaborolane moiety ensures excellent shelf-life and handling properties under inert conditions. Ideal for pharmaceutical research, agrochemical development, and materials science, this reagent is supplied as a crystalline solid with ≥95% purity (HPLC). Store under nitrogen at 2-8°C to maintain stability.

Category:

Description

3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS No. 865186-94-3) is a high-purity boronic ester derivative with the molecular formula C11H15BClNO2. This compound features a pyridine ring substituted with a chloro group at the 3-position and a pinacol boronate ester at the 5-position, making it a versatile intermediate for Suzuki-Miyaura cross-coupling reactions. Its stable dioxaborolane moiety ensures excellent shelf-life and handling properties under inert conditions. Ideal for pharmaceutical research, agrochemical development, and materials science, this reagent is supplied as a crystalline solid with ≥95% purity (HPLC). Store under nitrogen at 2-8°C to maintain stability.

Properties

  • CAS Number: 865186-94-3
  • Complexity: 257
  • IUPAC Name: 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
  • InChI: InChI=1S/C11H15BClNO2/c1-10(2)11(3,4)16-12(15-10)8-5-9(13)7-14-6-8/h5-7H,1-4H3
  • InChI Key: WCKBNAJTZUVHPD-UHFFFAOYSA-N
  • Exact Mass: 239.0884366
  • Molecular Formula: C11H15BClNO2
  • Molecular Weight: 239.51
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC(=CN=C2)Cl
  • Topological: 31.4
  • Monoisotopic Mass: 239.0884366
  • Synonyms: 865186-94-3, 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, DTXSID50631085, DTXCID30581837, 677-027-5, 5-Chloropyridine-3-boronic acid pinacol ester, 3-chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine, 5-Chloropyridine-3-boronic acid, pinacol ester, MFCD06798284, 3-chloro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, PYRIDINE, 3-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-, SCHEMBL1302755, WCKBNAJTZUVHPD-UHFFFAOYSA-N, AKOS015950280, Pyridine,3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, AB29944, BS-2122, CS-W000987, FD10013, SY057273, C3367, EN300-7383980, 2-(5-Chloro-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 3-chloro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine, 3-hydroxy-2,3-dimethylbutan-2-yl hydrogen 5-chloropyridin-3-ylboronate, 3-Chloro-5-(4 pound not4 pound not5 pound not5-tetramethyl-1 pound not3 pound not2-dioxaborolan-2-yl)pyridine

Application

This compound is widely used as a key building block in Suzuki-Miyaura cross-coupling reactions to introduce pyridyl boronate functionality into complex molecules. It finds applications in the synthesis of pharmaceutical candidates, particularly kinase inhibitors and CNS-targeting drugs. The chloro substituent allows for further functionalization via nucleophilic aromatic substitution.

Safety and Hazards

GHS Hazard Statements

  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (80%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

Reviews

There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.

Related products