Description

3-Chloro-4-methylaniline (CAS No. 95-74-9) is a high-purity organic compound with the molecular formula C₇H₈ClN. This aromatic amine, also known by its IUPAC name 3-chloro-4-methylaniline, is a versatile intermediate widely used in pharmaceutical, agrochemical, and dye synthesis. The compound features a chloro-substituted methylaniline structure, offering excellent reactivity for electrophilic substitution and coupling reactions.

Our product is rigorously tested to ensure ≥98% purity (GC), with low levels of impurities to meet the stringent demands of research and industrial applications. It is supplied as a crystalline solid or powder, packaged under inert conditions to ensure stability and longevity. Ideal for use in cross-coupling reactions, azo dye production, and as a precursor for specialized chemicals.

Available in quantities ranging from grams to bulk kilograms, with customizable packaging options including amber glass bottles and vacuum-sealed bags. Technical data sheets (TDS) and safety data sheets (SDS) are provided upon request.

Properties

• CAS Number: 95-74-9
• Complexity: 94.9
• IUPAC Name: 3-chloro-4-methyl-aniline
• InChI: InChI=1S/C7H8ClN/c1-5-2-3-6(9)4-7(5)8/h2-4H,9H2,1H3
• InChI Key: RQKFYFNZSHWXAW-UHFFFAOYSA-N
• Exact Mass: 141.0345270
• Molecular Formula: C7H8ClN
• Molecular Weight: 141.60
• SMILES: CC1=C(C=C(C=C1)N)Cl
• Topological: 26
• Monoisotopic Mass: 141.0345270
• Physical Description: 3-chloro-p-toluidine is a brown solid with a mild odor.
• Boiling Point: 468 to 471 °F at 760 mmHg
• Melting Point: 79 °F
• Flash Point: 212 °F
• Solubility: less than 1 mg/mL at 72 °F
• Density: 1.108 – Denser than water; will sink
• Vapor Pressure: 0.085 mmHg at 77 °F
• Autoignition Temperature: >/= 500 °C
• Dissociation Constants: pKa = 4.05
• Synonyms: 3-Chloro-4-methylaniline, 95-74-9, 3-CHLORO-P-TOLUIDINE, 4-Amino-2-chlorotoluene, Benzenamine, 3-chloro-4-methyl-, CCRIS 152, HSDB 2060, EINECS 202-446-3, UNII-32Y306W7BQ, BRN 0636511, DTXSID0020286, CHEBI:37824, 3-chloro-4-toluidine, DKC 1347, NSC-96620, DTXCID60286, EC 202-446-3, 4-12-00-01985 (Beilstein Handbook Reference), 3-Chloro-para-Toluidine, 3-CPT, o-Chlor-p-toluidin, 2Chloro4aminotoluene, 4Amino2chlorotoluene, pToluidine, 3chloro, 3Chloro4methylaniline, 4Methyl3chloroaniline, 2-Chlor-4-aminotoluol, 3Chloro4methylbenzenamine, 3Chloro4methylphenylamine, 1Amino3chloro4methylbenzene, Benzenamine, 3chloro4methyl, 4-Amino-2-chlor-1-methylbenzol, 4-AMINO-2-CHLOROTOLUENE[HSDB], inchi=1/c7h8cln/c1-5-2-3-6(9)4-7(5)8/h2-4h,9h2,1h, rqkfyfnzshwxaw-uhfffaoysa-n, un2239, 2-Chloro-4-aminotoluene, 3-Chloro-4-methylbenzenamine, 3-Chloro-4-methylphenylamine, 4-Methyl-3-chloroaniline, 1-Amino-3-chloro-4-methylbenzene, p-Toluidine, 3-chloro-, NCI-C02040, DRC 1339, 3-chloro-4-methyl-phenylamine, DRC 1347, NSC 96620, MFCD00007773, 32Y306W7BQ, 3-?Chloro-?4-?methylaniline, 3-chloro-4-methyl aniline, CAS-95-74-9, Aniline, 3-chloro-4-methyl-, 827571-80-2, 3-chloro 4-methylaniline, 2-chloro-4-amino-toluene, WLN: ZR CG D1, 3-chloranyl-4-methyl-aniline, MLS002303000, SCHEMBL349538, SCHEMBL1805666, SCHEMBL3956811, SCHEMBL9410515, CHEMBL1374337, 2-Chloro-4-aminotoluene, 98%, 3-Chloro-4-methylaniline, 98%, HMS3055G10, CS-M1324, NSC96620, STR02553, Tox21_201871, Tox21_302755, SBB004152, STK943762, AKOS000119158, FC64322, 4-AMINO-2-CHLOROTOLUENE [HSDB], NCGC00091083-01, NCGC00091083-02, NCGC00256599-01, NCGC00259420-01, SMR001252231, TS-01846, DB-024297, NS00005824, ST45255297, EN300-18377, D77417, A845453, Q7602061, Z57127543, F2190-0474, 3-Chloro-4-methylaniline, PESTANAL(R), analytical standard

Application

3-Chloro-4-methylaniline is a key intermediate in the synthesis of dyes, pigments, and pharmaceuticals, particularly in the production of azo dyes for textiles and specialty coatings. It is also utilized in agrochemical manufacturing as a precursor for herbicides and fungicides. Researchers employ this compound in organic synthesis for its reactivity in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig reactions.

Safety and Hazards

GHS Hazard Statements

• H301 (89.6%): Toxic if swallowed [Danger Acute toxicity, oral]
• H311 (85.4%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (93.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (87.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H319 (97.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (12.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H400 (89.6%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
• H410 (89.6%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P317, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P391, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (89.6%)
• Acute Tox. 3 (85.4%)
• Skin Irrit. 2 (93.8%)
• Skin Sens. 1 (87.5%)
• Eye Irrit. 2 (97.9%)
• Acute Tox. 4 (12.5%)
• Aquatic Acute 1 (89.6%)
• Aquatic Chronic 1 (89.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.