Description

3-Chloro-4-fluoroaniline (CAS No. 367-21-5) is a high-purity aromatic amine derivative with the molecular formula C₆H₅ClFN. This compound is a valuable intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. Its unique structure, featuring both chloro and fluoro substituents on the aniline ring, enables precise reactivity for cross-coupling reactions, diazotization, and other functional group transformations. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied as a clear to pale yellow liquid or crystalline solid, packaged under inert conditions to maintain stability. Ideal for researchers developing novel active ingredients, 3-Chloro-4-fluoroaniline is available in quantities ranging from grams to bulk kilograms with customizable packaging options.

Properties

• CAS Number: 367-21-5
• Complexity: 99.1
• IUPAC Name: 3-chloro-4-fluoro-aniline
• InChI: InChI=1S/C6H5ClFN/c7-5-3-4(9)1-2-6(5)8/h1-3H,9H2
• InChI Key: YSEMCVGMNUUNRK-UHFFFAOYSA-N
• Exact Mass: 145.0094550
• Molecular Formula: C6H5ClFN
• Molecular Weight: 145.56
• SMILES: C1=CC(=C(C=C1N)Cl)F
• Topological: 26
• Monoisotopic Mass: 145.0094550
• Synonyms: 3-CHLORO-4-FLUOROANILINE, 367-21-5, 3-Chloro-4-fluorobenzenamine, Benzenamine, 3-chloro-4-fluoro-, Aniline, 3-chloro-4-fluoro-, 3-Chloro-4-fluorophenylamine, 4-FLUORO-3-CHLOROANILINE, UNII-7L63CC70UQ, 7L63CC70UQ, EINECS 206-682-8, NSC 10290, NSC-10290, M-CHLORO-P-FLUOROANILINE, DTXSID0038754, DTXCID8018754, 206-682-8, inchi=1/c6h5clfn/c7-5-3-4(9)1-2-6(5)8/h1-3h,9h, ysemcvgmnuunrk-uhfffaoysa-n, 3-chloro-4-fluoro aniline, 3-chloro-4-fluoro-aniline, MFCD00007767, 3-Chloro-4-fluoroaniline(Chunks or pellets), 3-chloro-4-fluoro-phenylamine, Gefitinib Impurity V, 3-chloro4-fluoroaniline, Norfloxacin Intermediates, 3-Chloro-4-fluoroanilin, 3-chloro-4-flouroaniline, 3-chloro4-fluoro-aniline, 4-fluoro-3-chloro-aniline, SCHEMBL9602, 3chloro-4-fluoro-phenylamine, 4-fluoro-3-chlorophenylamine, SCHEMBL654920, 4-fluoro-3-chlorophenyl amine, SCHEMBL5148314, 4-fluoro-3-chloro phenyl amine, SCHEMBL28041210, 3-Chloro-4-fluoroaniline, 98%, BCP26715, HY-Y0680, NSC10290, SBB040458, STL164339, AKOS000119505, AC-2469, CS-W009142, FC34831, PS-8955, SB00006, DB-023935, NS00041709, ST45174782, EN300-20338, A15531, P19616, AG-617/02198034, Q27268500, F2190-0461, Z104477780, 3-Chloro-4-fluoroaniline;Benzenamine, 3-chloro-4-fluoro-

Application

3-Chloro-4-fluoroaniline serves as a key building block in the synthesis of pharmaceuticals, particularly for fluorinated drug candidates targeting CNS disorders and antibiotics. It is also employed in agrochemical research for developing herbicides and pesticides due to its halogenated aromatic structure. The compound’s reactivity allows for efficient incorporation into heterocyclic scaffolds via Buchwald-Hartwig amination or palladium-catalyzed cross-couplings.

Safety and Hazards

GHS Hazard Statements

• H301 (55.7%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (43%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (60.8%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H318 (36.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H331 (55.7%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H373 (60.8%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P361+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (55.7%)
• Acute Tox. 4 (43%)
• Acute Tox. 3 (60.8%)
• Eye Dam. 1 (36.7%)
• Acute Tox. 3 (55.7%)
• STOT RE 2 (60.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.