Description

3-Chloro-4-fluoro-5-(trifluoromethyl)aniline (CAS No. 914225-61-9) is a high-purity fluorinated aniline derivative with the molecular formula C₇H₄ClF₄N. This specialized aromatic amine features a unique combination of chloro, fluoro, and trifluoromethyl substituents, making it a valuable intermediate for pharmaceutical, agrochemical, and advanced material synthesis. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied as a crystalline solid with excellent batch-to-batch consistency. Proper storage under inert atmosphere at 2-8°C is recommended to maintain stability. Suitable for nucleophilic aromatic substitution, cross-coupling reactions, and as a building block for bioactive molecules. Available in research (5g, 25g) and bulk (100g, 1kg) quantities with optional custom purity and packaging.

Properties

• CAS Number: 914225-61-9
• Complexity: 184
• IUPAC Name: 3-chloro-4-fluoro-5-(trifluoromethyl)aniline
• InChI: InChI=1S/C7H4ClF4N/c8-5-2-3(13)1-4(6(5)9)7(10,11)12/h1-2H,13H2
• InChI Key: KAHNTLCBWGVHDY-UHFFFAOYSA-N
• Exact Mass: 212.9968395
• Molecular Formula: C7H4ClF4N
• Molecular Weight: 213.56
• SMILES: C1=C(C=C(C(=C1C(F)(F)F)F)Cl)N
• Topological: 26
• Monoisotopic Mass: 212.9968395
• Synonyms: 3-CHLORO-4-FLUORO-5-(TRIFLUOROMETHYL)ANILINE, 914225-61-9, MFCD09033155, SCHEMBL1799126, DTXSID30652293, AKOS015964866, DS-7061, SB78728, SY115255, 3-chloro-4-fluoro-5-trifluoromethylaniline, CS-0157735

Application

This fluorinated aniline derivative serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and antimicrobial agents. Its electron-deficient aromatic ring system enables efficient participation in palladium-catalyzed cross-coupling reactions for drug discovery applications. The compound is also employed in agrochemical research for developing novel herbicides and pesticides with enhanced metabolic stability. Researchers utilize its unique substitution pattern to study structure-activity relationships in medicinal chemistry programs.

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