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Atomfair 3-Chloro-2-iodopyridine C5H3ClIN CAS 77332-89-9

3-Chloro-2-iodopyridine (CAS No. 77332-89-9) is a high-purity halogenated pyridine derivative with the molecular formula C5H3ClIN , widely utilized in pharmaceutical and agrochemical research. This compound serves as a versatile building block for cross-coupling reactions (e.g., Suzuki, Stille, Negishi) due to its reactive iodine and chlorine substituents, enabling precise functionalization of the pyridine ring. Provided as a crystalline solid with ≥95% purity (HPLC), it is rigorously tested for consistency in batch-to-batch performance. Ideal for synthesizing ligands, catalysts, and bioactive molecules, it is packaged under inert conditions to ensure stability. Available in quantities from grams to kilograms, with optional custom purity and…

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Description

3-Chloro-2-iodopyridine (CAS No. 77332-89-9) is a high-purity halogenated pyridine derivative with the molecular formula C5H3ClIN, widely utilized in pharmaceutical and agrochemical research. This compound serves as a versatile building block for cross-coupling reactions (e.g., Suzuki, Stille, Negishi) due to its reactive iodine and chlorine substituents, enabling precise functionalization of the pyridine ring. Provided as a crystalline solid with ≥95% purity (HPLC), it is rigorously tested for consistency in batch-to-batch performance. Ideal for synthesizing ligands, catalysts, and bioactive molecules, it is packaged under inert conditions to ensure stability. Available in quantities from grams to kilograms, with optional custom purity and packaging.

Properties

  • CAS Number: 77332-89-9
  • Complexity: 78.8
  • IUPAC Name: 3-chloro-2-iodo-pyridine
  • InChI: InChI=1S/C5H3ClIN/c6-4-2-1-3-8-5(4)7/h1-3H
  • InChI Key: LTCHVAFYGVXKHH-UHFFFAOYSA-N
  • Exact Mass: 238.89987
  • Molecular Formula: C5H3ClIN
  • Molecular Weight: 239.44
  • SMILES: C1=CC(=C(N=C1)I)Cl
  • Topological: 12.9
  • Monoisotopic Mass: 238.89987
  • Synonyms: 3-chloro-2-iodopyridine, 77332-89-9, DTXSID00445770, DTXCID00396591, 811-259-1, Pyridine, 3-chloro-2-iodo-, 3-chloro-2-iodo-pyridine, chloro-iodopyridine, MFCD09258810, SCHEMBL229614, SCHEMBL366358, LTCHVAFYGVXKHH-UHFFFAOYSA-N, BCP04456, SBB051904, AKOS015891664, CS-W021896, PB43447, AS-18544, DB-011163

Application

3-Chloro-2-iodopyridine is a key intermediate in pharmaceutical synthesis, particularly for designing kinase inhibitors and antiviral agents. Its halogenated structure facilitates palladium-catalyzed couplings to construct complex heterocycles. Researchers also employ it in material science to develop functionalized ligands for metal-organic frameworks (MOFs).

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Acute Tox. 4 (100%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2 (100%)
  • Acute Tox. 4 (100%)
  • STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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