Description

3-Chloro-2-fluoro-propionic acid methyl ester (CAS No. 55900-27-1) is a high-purity fluorinated ester compound with the molecular formula C₄H₆ClFO₂. This specialty chemical, also known by its IUPAC name methyl 3-chloro-2-fluoropropanoate, is a valuable building block in organic synthesis and pharmaceutical intermediate preparation. The compound features both chloro and fluoro substituents on the propionate backbone, offering unique reactivity for nucleophilic substitution and cross-coupling reactions. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed containers under inert atmosphere to maintain stability. Suitable for research-scale applications and process development in medicinal chemistry, agrochemical synthesis, and materials science.

Properties

• CAS Number: 55900-27-1
• Complexity: 86.1
• IUPAC Name: methyl 3-chloro-2-fluoro-propanoate
• InChI: InChI=1S/C4H6ClFO2/c1-8-4(7)3(6)2-5/h3H,2H2,1H3
• InChI Key: RJKRCTOAJWVFOZ-UHFFFAOYSA-N
• Exact Mass: 140.0040353
• Molecular Formula: C4H6ClFO2
• Molecular Weight: 140.54
• SMILES: COC(=O)C(CCl)F
• Topological: 26.3
• Monoisotopic Mass: 140.0040353
• Synonyms: methyl 3-chloro-2-fluoropropanoate, 3-Chloro-2-fluoro-propionic acid methyl ester, EC 627-096-2, DTXSID001296238, DTXCID001726748, 627-096-2, 55900-27-1, Propanoic acid, 3-chloro-2-fluoro-, methyl ester, MFCD19159853, SCHEMBL2721193, Methyl 3-chloro-2-fluoropropionate, AKOS006223493, DB-198550, 3-Chloro-2-fluoropropanoic acid methyl ester, NS00006324

Application

3-Chloro-2-fluoro-propionic acid methyl ester serves as a versatile intermediate in the synthesis of fluorinated pharmaceutical compounds and bioactive molecules. Researchers utilize this ester in nucleophilic displacement reactions where the chloro group can be selectively substituted while preserving the fluoro substituent. The compound finds particular utility in the development of protease inhibitors and other target-specific therapeutics. Its bifunctional reactivity also makes it valuable for creating fluorinated polymers with specialized properties.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.