Description

3-Chloro-1,1,1-trifluoropropane (CAS No. 460-35-5) is a high-purity halogenated hydrocarbon with the molecular formula C₃H₄ClF₃. This colorless, volatile liquid is characterized by its trifluoromethyl group and reactive chloro substituent, making it a valuable intermediate in organic synthesis and industrial applications. Its IUPAC name, 3-chloro-1,1,1-trifluoropropane, reflects its precise molecular structure. With a boiling point of approximately 45-47°C and a density of 1.29 g/cm³, it is suitable for use as a solvent, refrigerant, or precursor in fluorochemical manufacturing. Packaged under inert gas to ensure stability, our product meets rigorous analytical standards (≥98% purity by GC) and is available in various quantities for laboratory and bulk use. Synonyms include Freon 253 and 1-chloro-3,3,3-trifluoropropane.

Properties

• CAS Number: 460-35-5
• Complexity: 48.6
• IUPAC Name: 3-chloro-1,1,1-trifluoro-propane
• InChI: InChI=1S/C3H4ClF3/c4-2-1-3(5,6)7/h1-2H2
• InChI Key: ZPIFKCVYZBVZIV-UHFFFAOYSA-N
• Exact Mass: 131.9953623
• Molecular Formula: C3H4ClF3
• Molecular Weight: 132.51
• SMILES: C(CCl)C(F)(F)F
• Monoisotopic Mass: 131.9953623
• Physical Description: 3-chloro-1,1,1-trifluoropropane appears as a colorless odorless nonflammable liquid. Poisonous by inhalation. Emits toxic fumes of chlorine and fluorine when heated to decomposition.
• Synonyms: 3-Chloro-1,1,1-trifluoropropane, 1-Chloro-3,3,3-trifluoropropane, 1,1,1-Trifluoro-3-chloropropane, Freon 253, PROPANE, 3-CHLORO-1,1,1-TRIFLUORO-, HCFC-253fb, 3,3,3-Trifluoro-1-chloropropane, EINECS 207-307-0, UNII-5C535H1OII, BRN 1734941, 5C535H1OII, CF3CH2CH2Cl, DTXSID5042033, 4-01-00-00193 (Beilstein Handbook Reference), 3,3,3-TRIFLUOROCHLOROPROPANE, DTXCID3022033, 207-307-0, zpifkcvyzbvziv-uhfffaoysa-n, 460-35-5, 3-Chloro-1,1,1-trifluoro-propane, Monochlorotrifluoropropane, HCFC-253, MFCD00069094, SCHEMBL578425, SCHEMBL4136640, SCHEMBL10648897, ALBB-025818, FD2078, SBB072694, AKOS005063772, AB02799, AS-60539, DB-008293, CS-0022351, NS00043630, ST45028954, 3-Chloro-1,1,1-trifluoropropane, AldrichCPR, Q27261813

Application

3-Chloro-1,1,1-trifluoropropane serves as a versatile building block in pharmaceutical and agrochemical synthesis, particularly for introducing trifluoromethyl groups. It is employed as a refrigerant (Freon 253) in specialized cooling systems due to its low global warming potential compared to traditional CFCs. Additionally, its reactivity as an alkylating agent makes it useful in polymer chemistry and fine chemical production. Researchers also utilize it as a solvent for fluorinated compounds in analytical and material science applications.

Safety and Hazards

GHS Hazard Statements

• H301 (50%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (50%): Toxic if inhaled [Danger Acute toxicity, inhalation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P304+P340, P305+P351+P338, P316, P321, P330, P337+P317, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (50%)
• Acute Tox. 4 (50%)
• Eye Irrit. 2 (50%)
• Acute Tox. 3 (50%)

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