Description

3-Bromo-5-(trifluoromethyl)pyridine (CAS No. 436799-33-6) is a high-purity halogenated pyridine derivative with the molecular formula C₆H₃BrF₃N. This compound features a bromine substituent at the 3-position and a trifluoromethyl group at the 5-position of the pyridine ring, offering unique reactivity for nucleophilic substitution and cross-coupling reactions. Ideal for pharmaceutical, agrochemical, and materials science research, it is supplied as a clear to pale-yellow liquid or low-melting solid with ≥98% purity (GC). Store under inert conditions at 2-8°C to prevent degradation. Available in amber glass vials (100mg to 25g) with optional COA and NMR spectra.

Properties

• CAS Number: 436799-33-6
• Complexity: 136
• IUPAC Name: 3-bromo-5-(trifluoromethyl)pyridine
• InChI: InChI=1S/C6H3BrF3N/c7-5-1-4(2-11-3-5)6(8,9)10/h1-3H
• InChI Key: HEDHNDVPKRVQPN-UHFFFAOYSA-N
• Exact Mass: 224.94010
• Molecular Formula: C6H3BrF3N
• Molecular Weight: 225.99
• SMILES: C1=C(C=NC=C1Br)C(F)(F)F
• Topological: 12.9
• Monoisotopic Mass: 224.94010
• Synonyms: 3-Bromo-5-(trifluoromethyl)pyridine, 436799-33-6, DTXSID50456230, DTXCID90407049, 626-819-9, 3-bromo-5-trifluoromethyl-pyridine, MFCD04972700, Pyridine, 3-bromo-5-(trifluoromethyl)-, 5-bromo-3-(trifluoromethyl)pyridine, 3-bromo-5-trifluoromethylpyridine, 3-Bromo-5-trfluoromethylpyridine, 3-Trifluoromethyl-5-bromopyridine, SCHEMBL185547, SCHEMBL944873, SCHEMBL6304070, 3-bromo-5-trifluoromethylpyridin, BBL102933, SBB054386, STL556742, 3-Bromo-5- (trifluoromethyl)pyridine, AKOS005063455, CS-W007687, PB32382, PS-6390, AC-23349, SY013774, 3-Bromo-5-(trifluoromethyl)pyridine, 97%, B4710, ST51042315, EN300-103363

Application

3-Bromo-5-(trifluoromethyl)pyridine serves as a versatile building block in Suzuki-Miyaura and Buchwald-Hartwig couplings for drug discovery, particularly in kinase inhibitor development. The trifluoromethyl group enhances metabolic stability in agrochemical candidates, while the bromine enables palladium-catalyzed functionalization for material science applications. Researchers value its utility in creating fluorinated liquid crystals and electronic materials.

Safety and Hazards

GHS Hazard Statements

• H300 (81.6%): Fatal if swallowed [Danger Acute toxicity, oral]
• H302 (12.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (98%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 2 (81.6%)
• Acute Tox. 4 (12.2%)
• Skin Irrit. 2 (98%)
• Eye Irrit. 2 (98%)
• STOT SE 3 (95.9%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.