Description

Description

3-Bromo-5-(trifluoromethyl)benzaldehyde (CAS No. 477535-41-4) is a high-purity aromatic aldehyde featuring both bromo and trifluoromethyl functional groups, making it a versatile building block for advanced organic synthesis. This compound, with the molecular formula C₈H₄BrF₃O, is a valuable intermediate in pharmaceutical, agrochemical, and materials science research. Its unique structure enables selective modifications, particularly in cross-coupling reactions and nucleophilic substitutions. Supplied as a crystalline solid with >95% purity (HPLC), it is rigorously tested for consistency and stability. Ideal for use in Suzuki-Miyaura couplings, Grignard reactions, and as a precursor for heterocyclic compounds. Packaged under inert gas to ensure longevity and stored in amber vials to prevent degradation.

Application

3-Bromo-5-(trifluoromethyl)benzaldehyde is widely employed in medicinal chemistry for the synthesis of bioactive molecules, particularly those targeting CNS disorders and inflammation. Its trifluoromethyl group enhances metabolic stability in drug candidates, while the bromo substituent facilitates palladium-catalyzed cross-couplings. Researchers also utilize it in material science to develop liquid crystals and OLED intermediates. The compound’s reactivity with amines and hydrazines makes it valuable for constructing Schiff bases and heterocycles like indoles and quinolines.

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