Description

3-Bromo-5-nitropyridine (CAS No. 15862-30-3) is a high-purity heterocyclic organic compound with the molecular formula C₅H₃BrN₂O₂. This brominated nitropyridine derivative is a versatile building block in pharmaceutical and agrochemical synthesis, offering excellent reactivity for nucleophilic substitution and cross-coupling reactions. The compound features a nitro group at the 5-position and a bromine substituent at the 3-position of the pyridine ring, enabling selective functionalization. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a crystalline solid with optimal stability. Suitable for use in Suzuki-Miyaura coupling, Buchwald-Hartwig amination, and other transition-metal catalyzed reactions. Packaged under inert gas to prevent degradation.

Key Specifications:
• CAS: 15862-30-3
• Molecular Weight: 202.99 g/mol
• Melting Point: 92-96°C
• Storage: 2-8°C under inert atmosphere
• Hazard Codes: Xi (Irritant)

Properties

• CAS Number: 15862-30-3
• Complexity: 136
• IUPAC Name: 3-bromo-5-nitro-pyridine
• InChI: InChI=1S/C5H3BrN2O2/c6-4-1-5(8(9)10)3-7-2-4/h1-3H
• InChI Key: WHYJVHQKKJHXTB-UHFFFAOYSA-N
• Exact Mass: 201.93779
• Molecular Formula: C5H3BrN2O2
• Molecular Weight: 202.99
• SMILES: C1=C(C=NC=C1Br)[N+](=O)[O-]
• Topological: 58.7
• Monoisotopic Mass: 201.93779
• Synonyms: 3-Bromo-5-nitropyridine, 15862-30-3, DTXSID80376553, DTXCID40327581, 677-831-6, PYRIDINE, 3-BROMO-5-NITRO-, 3-bromo-5-nitro-pyridine, MFCD04114216, SCHEMBL529746, SCHEMBL4060658, SCHEMBL11724286, WHYJVHQKKJHXTB-UHFFFAOYSA-N, CL0163, 3-Bromo-5-nitropyridine, AldrichCPR, AKOS015833832, AB17991, CS-W003163, GS-6476, AC-22569, SY005917, DB-032334, EN300-108183

Application

3-Bromo-5-nitropyridine serves as a key intermediate in the synthesis of bioactive molecules, particularly in developing kinase inhibitors and antimicrobial agents. The compound’s orthogonal reactivity allows sequential modification of both halogen and nitro groups for structure-activity relationship studies. Researchers utilize this building block in fragment-based drug discovery and material science applications. Its electron-deficient pyridine core makes it valuable for constructing conjugated systems in organic electronics.

Safety and Hazards

GHS Hazard Statements

• H301 (88.9%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (11.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (11.1%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (11.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (88.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (11.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (11.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (88.9%)
• Acute Tox. 4 (11.1%)
• Acute Tox. 4 (11.1%)
• Skin Irrit. 2 (11.1%)
• Eye Dam. 1 (88.9%)
• Eye Irrit. 2A (11.1%)
• STOT SE 3 (11.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.