Description

3-Bromo-5-methylpyridin-4-amine (CAS No. 97944-43-9) is a high-purity brominated pyridine derivative with the molecular formula C₆H₇BrN₂. This compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring a reactive bromine substituent and an amine group on the pyridine ring, makes it an ideal intermediate for cross-coupling reactions, nucleophilic substitutions, and heterocyclic scaffold modifications. Our product is rigorously tested for quality (≥95% purity by HPLC) and supplied in sealed packaging under inert conditions to ensure stability. Suitable for use in medicinal chemistry, material science, and as a ligand precursor.

Properties

• CAS Number: 97944-43-9
• Complexity: 97.1
• IUPAC Name: 3-bromo-5-methyl-pyridin-4-amine
• InChI: InChI=1S/C6H7BrN2/c1-4-2-9-3-5(7)6(4)8/h2-3H,1H3,(H2,8,9)
• InChI Key: GUAFGBUKLIFASX-UHFFFAOYSA-N
• Exact Mass: 185.97926
• Molecular Formula: C6H7BrN2
• Molecular Weight: 187.04
• SMILES: CC1=CN=CC(=C1N)Br
• Topological: 38.9
• Monoisotopic Mass: 185.97926
• Synonyms: 3-Bromo-5-methylpyridin-4-amine, 97944-43-9, DTXSID90540243, DTXCID00491030, 845-759-6, 4-Amino-3-bromo-5-methylpyridine, 3-Bromo-5-methyl-pyridin-4-ylamine, MFCD07437841, 4-Amino-5-bromo-3-methylpyridine, 4-Pyridinamine, 3-bromo-5-methyl-, 4-Pyridinamine,3-bromo-5-methyl-, SCHEMBL14206718, SCHEMBL23234761, GUAFGBUKLIFASX-UHFFFAOYSA-N, AKOS006284117, GS-5725, SB40341, AC-33416, SY066924, DB-024936, CS-0042800, EN300-105074, Z1198173286

Application

3-Bromo-5-methylpyridin-4-amine serves as a key intermediate in the synthesis of biologically active compounds, including kinase inhibitors and antimicrobial agents. Its bromine moiety enables participation in Suzuki-Miyaura and Buchwald-Hartwig couplings for drug discovery. Researchers also utilize it to modify pyridine-based ligands in catalysis. The methyl and amine groups further enhance its utility in structure-activity relationship (SAR) studies.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)

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