Atomfair 3-Bromo-5-hydroxypyridine C5H4BrNO CAS 74115-13-2

Description

3-Bromo-5-hydroxypyridine (CAS No. 74115-13-2) is a high-purity heterocyclic organic compound with the molecular formula C₅H₄BrNO. This brominated pyridine derivative is a versatile building block in pharmaceutical, agrochemical, and materials science research. The compound features a hydroxyl group at the 5-position and a bromine substituent at the 3-position of the pyridine ring, offering two reactive sites for further functionalization.

Our product is synthesized under strict quality control measures, ensuring >98% purity (HPLC) and optimal batch-to-batch consistency. The white to off-white crystalline powder is supplied in amber glass vials under inert atmosphere to ensure long-term stability. Suitable for nucleophilic aromatic substitution, metal-catalyzed cross-coupling reactions (Buchwald-Hartwig, Suzuki-Miyaura), and as a precursor for kinase inhibitors.

Key specifications include: Molecular Weight: 174.00 g/mol, Melting Point: 145-148°C, Storage Conditions: 2-8°C under inert gas. Packaged in 1g, 5g, and 25g quantities with optional COA and NMR spectra upon request.

Properties

• CAS Number: 74115-13-2
• Complexity: 78.8
• IUPAC Name: 5-bromopyridin-3-ol
• InChI: InChI=1S/C5H4BrNO/c6-4-1-5(8)3-7-2-4/h1-3,8H
• InChI Key: VNYBIBSZZDAEOK-UHFFFAOYSA-N
• Exact Mass: 172.94763
• Molecular Formula: C5H4BrNO
• Molecular Weight: 174.00
• SMILES: C1=C(C=NC=C1Br)O
• Topological: 33.1
• Monoisotopic Mass: 172.94763
• Synonyms: 3-Bromo-5-hydroxypyridine, 74115-13-2, 5-Bromo-3-pyridinol, DTXSID40344793, DTXCID50295868, 627-764-3, 5-bromopyridin-3-ol, 5-Bromo-3-hydroxypyridine, 3-Bromo-5-pyridinol, 5-Bromo-pyridin-3-ol, 3-Pyridinol, 5-bromo-, MFCD00661305, Pyridine, 3-ol-5-bromo-, 3-HYDROXY-5-BROMOPYRIDINE, 5-bromopyrid-3-ol, 5-bromopyridine-3-ol, 5-bromanylpyridin-3-ol, 5-Bromo-3-pyridinol #, 5-Bromo-3-hydroxylpyridine, SCHEMBL7676, 3-bromo-5-hydroxy pyridine, 5-bromo-3-hydroxy-pyridine, Pyridine, 3-hydroxy-5-bromo-, SCHEMBL27610934, 3-Bromo-5-hydroxypyridine, 97%, BBL102908, RB1128, SBB081337, STL556717, AKOS000275939, AC-3094, CS-W019637, FB19156, PB30658, PS-6098, HY-66053, SY003815, DB-024960, B3969, EN300-75258, A838021, AC-907/30002047, Z1172207821

Application

3-Bromo-5-hydroxypyridine serves as a critical intermediate in medicinal chemistry for developing kinase-targeted therapeutics, particularly in cancer research. The compound’s orthogonal reactivity enables efficient synthesis of poly-substituted pyridine scaffolds for drug discovery programs. Researchers utilize this building block in fragment-based ligand design and as a precursor for PET tracer development. Its structural features make it valuable for creating novel heterocyclic compounds with potential biological activity.

Safety and Hazards

GHS Hazard Statements

• H302 (85.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (85.7%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.