Description

3-Bromo-5-fluoropyridine (CAS No. 407-20-5) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₃BrFN. This heterocyclic compound is a valuable building block in organic synthesis, pharmaceutical research, and agrochemical development. Its unique structure, featuring both bromine and fluorine substituents on the pyridine ring, makes it an excellent precursor for cross-coupling reactions such as Suzuki, Stille, and Negishi couplings. With a purity of ≥97%, this product is ideal for researchers requiring precise and reliable intermediates for complex molecule construction. Supplied in tightly sealed containers under inert atmosphere to ensure stability and longevity, 3-Bromo-5-fluoropyridine is a must-have for medicinal chemists and material scientists working on fluorinated compounds or heterocyclic scaffolds.

Properties

• CAS Number: 407-20-5
• Complexity: 78.8
• IUPAC Name: 3-bromo-5-fluoro-pyridine
• InChI: InChI=1S/C5H3BrFN/c6-4-1-5(7)3-8-2-4/h1-3H
• InChI Key: HNNNBQRRIHKFLI-UHFFFAOYSA-N
• Exact Mass: 174.94329
• Molecular Formula: C5H3BrFN
• Molecular Weight: 175.99
• SMILES: C1=C(C=NC=C1Br)F
• Topological: 12.9
• Monoisotopic Mass: 174.94329
• Synonyms: 3-bromo-5-fluoropyridine, 407-20-5, DTXSID80356173, DTXCID90307232, 627-401-9, 5-Bromo-3-fluoropyridine, MFCD04112555, 3-fluoro-5-bromopyridine, 3-Bromo-5-fluoro-pyridine, 3-bromo-5-fluoro pyridine, Pyridine, 3-bromo-5-fluoro-, 3-Bromo-5-fluoropyridine?, SCHEMBL432021, SCHEMBL4923645, SCHEMBL4929063, SCHEMBL4930635, 3-Bromo-5-fluoropyridine, 97%, BCP04824, BBL102672, SBB054265, STL556476, AKOS005063996, AC-7011, CS-W001250, FB07700, PB42777, PS-8596, SY003442, DB-006980, B3244, ST50408685, EN300-52981, 5-Fluoro-3-bromopyridine5-Bromo-3-fluoropyridine, AO-160/25072004

3-Bromo-5-fluoropyridine serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. Its reactive bromine and fluorine groups enable facile functionalization for drug discovery programs targeting CNS and oncology applications. The compound is particularly useful in palladium-catalyzed cross-coupling reactions to create biaryl structures common in many therapeutic agents. Researchers also employ this building block in the development of liquid crystal materials and electronic chemicals where fluorinated pyridines enhance performance characteristics.

Safety and Hazards

GHS Hazard Statements

• H302 (98%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (98%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (86.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (11.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (11.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (96.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (98%)
• Skin Irrit. 2 (98%)
• Eye Dam. 1 (86.3%)
• Eye Irrit. 2 (11.8%)
• STOT SE 3 (96.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.