Description

3-Bromo-5-chloro-2-fluoropyridine (CAS No. 884494-87-5) is a high-purity halogenated pyridine derivative widely utilized in pharmaceutical and agrochemical research. This compound, with the molecular formula C₅H₂BrClFN, serves as a versatile building block for the synthesis of complex heterocyclic frameworks. Its unique substitution pattern (bromo, chloro, and fluoro groups on the pyridine ring) enables selective functionalization, making it invaluable for medicinal chemistry and material science applications. Available in >98% purity (HPLC), this product is rigorously tested for consistency and stability, ensuring optimal performance in cross-coupling reactions, nucleophilic substitutions, and other synthetic transformations. Packaged under inert gas to prevent degradation, it is supplied in amber glass vials or bulk quantities to meet your research needs.

Properties

• CAS Number: 884494-87-5
• Complexity: 103
• IUPAC Name: 3-bromo-5-chloro-2-fluoro-pyridine
• InChI: InChI=1S/C5H2BrClFN/c6-4-1-3(7)2-9-5(4)8/h1-2H
• InChI Key: FKHJIEHQWOYVQM-UHFFFAOYSA-N
• Exact Mass: 208.90432
• Molecular Formula: C5H2BrClFN
• Molecular Weight: 210.43
• SMILES: C1=C(C=NC(=C1Br)F)Cl
• Topological: 12.9
• Monoisotopic Mass: 208.90432
• Synonyms: 3-Bromo-5-chloro-2-fluoropyridine, 884494-87-5, MFCD04972409, 3-BROMO-2-FLUORO-5-CHLOROPYRIDINE, 2-fluoro-3-bromo-5-chloropyridine, 3-bromo-5-chloro-2-fluoro-pyridine, SCHEMBL440236, FKHJIEHQWOYVQM-UHFFFAOYSA-N, 5-Chloro-3-bromo-2-fluoropyridine, SBB094382, AKOS007929935, AB20989, AC-7015, CS-W003210, AS-17753, SY014354, DB-004301, DB-031385, EN300-315907, 937379-60-7

Application

3-Bromo-5-chloro-2-fluoropyridine is a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals, particularly for compounds targeting kinase inhibition or pest control. Its halogen-rich structure facilitates Suzuki-Miyaura and Buchwald-Hartwig couplings to construct biaryl or aminopyridine scaffolds. Researchers also employ it in fluorination studies or as a precursor for radiopharmaceutical labeling due to its reactive bromo and chloro sites. The electron-deficient pyridine core enhances its utility in metal-organic framework (MOF) design and ligand synthesis.

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