Description

3-Bromo-2-chloropyridine (CAS: 52200-48-3) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₃BrClN, widely utilized in pharmaceutical, agrochemical, and material science research. This heterocyclic compound serves as a versatile building block for synthesizing complex molecules due to its reactive bromo and chloro substituents, enabling selective cross-coupling reactions such as Suzuki, Stille, and Buchwald-Hartwig aminations. With a purity of ≥98%, it is supplied as a white to off-white crystalline solid, ensuring consistency in synthetic applications. Its stability under inert conditions and compatibility with organometallic catalysts make it ideal for medicinal chemistry and ligand design. Packaged in amber glass vials under nitrogen to prevent degradation, it is ideal for high-throughput screening and custom synthesis.

Properties

• CAS Number: 52200-48-3
• Complexity: 78.8
• IUPAC Name: 3-bromo-2-chloro-pyridine
• InChI: InChI=1S/C5H3BrClN/c6-4-2-1-3-8-5(4)7/h1-3H
• InChI Key: HDYNIWBNWMFBDO-UHFFFAOYSA-N
• Exact Mass: 190.91374
• Molecular Formula: C5H3BrClN
• Molecular Weight: 192.44
• SMILES: C1=CC(=C(N=C1)Cl)Br
• Topological: 12.9
• Monoisotopic Mass: 190.91374
• Synonyms: 3-Bromo-2-chloropyridine, 52200-48-3, HDYNIWBNWMFBDO-UHFFFAOYSA-, DTXSID40351220, DTXCID90302287, 629-254-6, inchi=1/c5h3brcln/c6-4-2-1-3-8-5(4)7/h1-3h, 2-Chloro-3-bromopyridine, MFCD00234007, 3-Bromo-2-chlorolpyridine, 3-bromo-2-chloro-pyridine, PYRIDINE, 3-BROMO-2-CHLORO-, SCHEMBL122934, SCHEMBL229172, SCHEMBL1989964, SCHEMBL3603413, 3-Bromo-2-chloropyridine, 98%, HDYNIWBNWMFBDO-UHFFFAOYSA-N, BCP26359, CS-B1311, BBL101501, CL0158, SBB003618, STL555297, AKOS000272820, AC-7016, PB33875, PS-5357, BP-10118, HY-32751, SY004419, DB-027603, B2328, ST50208062, EN300-54306, AC-907/25004333, F3099-7216, Z808600354

3-Bromo-2-chloropyridine is a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals, particularly in modifying pyridine cores for drug discovery. It facilitates palladium-catalyzed coupling reactions to construct biaryl systems or introduce functional groups. Researchers also employ it in material science for developing organic semiconductors and photoactive compounds. Its dual halogen reactivity allows sequential functionalization, enabling diverse structural diversification.

Safety and Hazards

GHS Hazard Statements

• H302 (10.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (10.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (10.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.8%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.