Description

3-Bromo-2-chloro-5-methylpyridine (CAS No. 17282-03-0) is a high-purity halogenated pyridine derivative widely used in pharmaceutical and agrochemical research. This compound, with the molecular formula C₆H₅BrClN, serves as a versatile building block for synthesizing complex heterocyclic compounds. Its unique structure, featuring bromo and chloro substituents at the 3 and 2 positions respectively, along with a methyl group at the 5 position, makes it invaluable for cross-coupling reactions, nucleophilic substitutions, and other functional group transformations. Available in >98% purity, this product is rigorously tested via GC/MS, HPLC, and NMR to ensure consistency for demanding applications. Suitable for use in medicinal chemistry, material science, and as an intermediate in active pharmaceutical ingredient (API) development. Packaged under inert gas to ensure stability and shipped with comprehensive analytical data.

Properties

• CAS Number: 17282-03-0
• Complexity: 99.1
• IUPAC Name: 3-bromo-2-chloro-5-methyl-pyridine
• InChI: InChI=1S/C6H5BrClN/c1-4-2-5(7)6(8)9-3-4/h2-3H,1H3
• InChI Key: ISNRJFOYJNIKTN-UHFFFAOYSA-N
• Exact Mass: 204.92939
• Molecular Formula: C6H5BrClN
• Molecular Weight: 206.47
• SMILES: CC1=CC(=C(N=C1)Cl)Br
• Topological: 12.9
• Monoisotopic Mass: 204.92939
• Synonyms: 3-bromo-2-chloro-5-methylpyridine, 17282-03-0, DTXSID30301315, DTXCID80252449, 829-658-4, 2-Chloro-3-bromo-5-methylpyridine, 3-bromo-2-chloro-5-picoline, MFCD01830664, 5-bromo-6-chloro-3-picoline, PYRIDINE, 3-BROMO-2-CHLORO-5-METHYL-, 3-bromo-2-chloro-5-methyl-pyridine, NSC142315, 2-Chloro-3-Bromo-5-Methyl Pyridine, SCHEMBL761533, SCHEMBL27759683, ISNRJFOYJNIKTN-UHFFFAOYSA-N, BCP22233, CS-D0948, SBB093733, AKOS005258275, AB09970, DS-1330, NSC 142315, NSC-142315, AC-24921, BP-10313, SY018253, DB-023775, B5061, EN300-159822, AE-473/30224034

3-Bromo-2-chloro-5-methylpyridine is primarily employed as a key intermediate in the synthesis of pharmaceuticals and agrochemicals. Its reactive halogen sites enable efficient Suzuki, Stille, or Buchwald-Hartwig coupling reactions for constructing biaryl systems. Researchers utilize this compound in the development of kinase inhibitors and other biologically active molecules. It also finds application in material science for creating functionalized pyridine-based ligands.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (50%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.