Description

3-Bromo-2-chloro-5-fluoropyridine (CAS No. 884494-36-4) is a high-purity halogenated pyridine derivative designed for advanced chemical synthesis and pharmaceutical research. With the molecular formula C₅H₂BrClFN, this compound serves as a versatile building block in the development of agrochemicals, pharmaceuticals, and specialty materials. Its unique substitution pattern (bromo, chloro, and fluoro groups) enables selective functionalization, making it invaluable for cross-coupling reactions, nucleophilic substitutions, and other fine chemical transformations. Packaged under inert conditions to ensure stability, this product is rigorously tested via GC/MS, HPLC, and ¹H/¹³C NMR to meet >98% purity standards. Suitable for use in GMP-compliant environments and available in scalable quantities (mg to kg).

Properties

• CAS Number: 884494-36-4
• Complexity: 103
• IUPAC Name: 3-bromo-2-chloro-5-fluoro-pyridine
• InChI: InChI=1S/C5H2BrClFN/c6-4-1-3(8)2-9-5(4)7/h1-2H
• InChI Key: NKUUDYHEWVWETB-UHFFFAOYSA-N
• Exact Mass: 208.90432
• Molecular Formula: C5H2BrClFN
• Molecular Weight: 210.43
• SMILES: C1=C(C=NC(=C1Br)Cl)F
• Topological: 12.9
• Monoisotopic Mass: 208.90432
• Synonyms: 3-BROMO-2-CHLORO-5-FLUOROPYRIDINE, 884494-36-4, DTXSID60654063, DTXCID30604813, 802-251-9, MFCD03095269, 3-Bromo-5-fluoro-2-chloropyridine, SCHEMBL933261, NKUUDYHEWVWETB-UHFFFAOYSA-N, CS-D0949, AKOS015853569, AB13638, AS-17692, SY017764, DB-024946, EN300-94706, 3-Bromo-5-fluoro-2-chloropyridine;5-Fluoro-2-chloro-3-bromopyridine;5-Fluoro-3-bromo-2-chloropyridine;2-Chloro-3-bromo-5-fluoropyridine;2-Chloro-5-fluoro-3-bromopyridine

3-Bromo-2-chloro-5-fluoropyridine is widely employed as a key intermediate in pharmaceutical R&D, particularly for synthesizing fluorinated pyridine-based active ingredients. Its reactivity facilitates the construction of complex heterocycles in drug candidates targeting CNS disorders and oncology. In agrochemistry, it acts as a precursor for novel pesticides and herbicides. The compound’s halogen-rich structure also supports materials science applications, such as liquid crystal and polymer modifiers.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.