Description

3-Amino-5-bromo-2-chloropyridine (CAS No. 588729-99-1) is a high-purity halogenated pyridine derivative widely used in pharmaceutical and agrochemical research. With the molecular formula C₅H₄BrClN₂, this compound serves as a versatile intermediate in organic synthesis, particularly in the development of active pharmaceutical ingredients (APIs) and specialty chemicals. Its unique structure, featuring both bromo and chloro substituents, allows for selective functionalization via cross-coupling reactions, nucleophilic substitutions, and other key transformations.

This product is supplied as a fine crystalline powder with ≥97% purity (GC), ensuring optimal performance in sensitive applications. It is rigorously tested for impurities, moisture content, and stability to meet the stringent demands of industrial and academic researchers. Proper storage in a cool, dry place under inert atmosphere is recommended to maintain its integrity.

Applications include use as a building block in Suzuki-Miyaura couplings, Buchwald-Hartwig aminations, and other palladium-catalyzed reactions. It is also employed in the synthesis of heterocyclic compounds with potential biological activity. Available in customizable quantities from milligrams to kilograms, this product is ideal for both small-scale R&D and large-scale production.

Properties

• CAS Number: 588729-99-1
• Complexity: 101
• IUPAC Name: 5-bromo-2-chloro-pyridin-3-amine
• InChI: InChI=1S/C5H4BrClN2/c6-3-1-4(8)5(7)9-2-3/h1-2H,8H2
• InChI Key: ZSEZSALOLWCCGT-UHFFFAOYSA-N
• Exact Mass: 205.92464
• Molecular Formula: C5H4BrClN2
• Molecular Weight: 207.45
• SMILES: C1=C(C=NC(=C1N)Cl)Br
• Topological: 38.9
• Monoisotopic Mass: 205.92464
• Synonyms: 3-Amino-5-bromo-2-chloropyridine, 675-552-4, 588729-99-1, 5-Bromo-2-chloropyridin-3-amine, 2-Chloro-3-amino-5-bromopyridine, MFCD02682092, 5-Bromo-2-chloro-3-pyridinamine, 3-Pyridinamine, 5-bromo-2-chloro-, 5-bromo-2-chloro-3-pyridylamine, 5-bromo-2-chloro-pyridin-3-ylamine, 5-BROMO-2-CHLORO-3-AMINOPYRIDINE, SCHEMBL116402, DTXSID20618904, ZSEZSALOLWCCGT-UHFFFAOYSA-N, 5-bromo-2-chloropyridine-3-amine, 5-Bromo-2-chloropyridin-3-ylamine, BCP22079, CS-D0976, BBL100667, SBB051893, STL554461, AKOS005145607, AC-5426, FA15342, PB21183, PS-4682, SB10347, 3-Amino-5-bromo-2-chloropyridine, 97%, HY-32828, SY016469, DB-024932, A2540, EN300-107028, 2-Chloro-3-amino-5-bromopyridine ;5-Bromo-2-chloropyridin-3-amine, 2-Chloro-3-amino-5-bromopyridine;5-Bromo-2-chloropyridin-3-amine

3-Amino-5-bromo-2-chloropyridine is a key intermediate in the synthesis of pharmaceuticals, particularly kinase inhibitors and antiviral agents. Its reactive sites enable efficient derivatization for drug discovery pipelines. The compound is also utilized in material science for constructing complex nitrogen-containing heterocycles. Researchers value its stability and compatibility with modern synthetic methodologies.

Safety and Hazards

GHS Hazard Statements

• H301 (85.4%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (10.4%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (10.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (85.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (14.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (85.4%)
• Acute Tox. 4 (10.4%)
• Acute Tox. 4 (10.4%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (85.4%)
• Eye Irrit. 2 (14.6%)
• STOT SE 3 (97.9%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.