Description

3-Amino-4-(trifluoromethyl)pyridine (CAS No. 175204-80-5) is a high-purity heterocyclic compound with the molecular formula C₆H₅F₃N₂. This specialized pyridine derivative features an amino group at the 3-position and a trifluoromethyl group at the 4-position, offering unique reactivity and physicochemical properties. With an IUPAC name of 4-(trifluoromethyl)pyridin-3-amine, this compound is ideal for pharmaceutical research, agrochemical development, and materials science applications. Our product is rigorously tested for purity and consistency, ensuring reliable performance in synthetic transformations. Available in research quantities with comprehensive analytical data (GC/MS, NMR, HPLC).

Properties

• CAS Number: 175204-80-5
• Complexity: 134
• IUPAC Name: 4-(trifluoromethyl)pyridin-3-amine
• InChI: InChI=1S/C6H5F3N2/c7-6(8,9)4-1-2-11-3-5(4)10/h1-3H,10H2
• InChI Key: DROFUWWORPKKSI-UHFFFAOYSA-N
• Exact Mass: 162.04048265
• Molecular Formula: C6H5F3N2
• Molecular Weight: 162.11
• SMILES: C1=CN=CC(=C1C(F)(F)F)N
• Topological: 38.9
• Monoisotopic Mass: 162.04048265
• Synonyms: 3-Amino-4-(trifluoromethyl)pyridine, 175204-80-5, 3-amino-4-trifluoromethylpyridine, DTXSID60371046, DTXCID30322080, 670-887-2, 4-(trifluoromethyl)pyridin-3-amine, 3-Pyridinamine, 4-(trifluoromethyl)-, MFCD00173960, 4-trifluoromethyl-pyridin-3-ylamine, SCHEMBL971004, SCHEMBL2068190, GJOMVBPTYCNYOS-UHFFFAOYSA-N, 4-Trifluoromethyl-3-pyridinylamine, 4-(trifluoromethyl)-3-pyridylamine, BCP26953, CCG-51268, SBB051897, AKOS005063697, AB04387, FS-1069, AC-22649, SY022758, DB-002543, A2971, CS-0005664, EN300-112837, SR-01000640575-1, Z1201619543

Application

3-Amino-4-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, particularly for developing bioactive molecules targeting CNS disorders. The trifluoromethyl group enhances metabolic stability and lipophilicity, making it valuable for drug discovery programs. This intermediate is also employed in catalytic systems and as a ligand precursor in coordination chemistry.

Safety and Hazards

GHS Hazard Statements

• H301 (33.3%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (33.3%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (33.3%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H335 (33.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (33.3%)
• Acute Tox. 4 (33.3%)
• Acute Tox. 3 (33.3%)
• Skin Irrit. 2 (66.7%)
• Eye Irrit. 2 (66.7%)
• Acute Tox. 3 (33.3%)
• STOT SE 3 (33.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.