Description

3-Amino-4-fluorophenol (CAS No. 62257-16-3) is a high-purity fluorinated aromatic compound with the molecular formula C₆H₆FNO. This fine chemical is characterized by its amino and hydroxyl functional groups, making it a versatile intermediate for pharmaceutical, agrochemical, and material science applications. With a molecular weight of 127.12 g/mol, it is supplied as a crystalline solid with ≥98% purity (HPLC), ensuring consistency for research and industrial processes. Ideal for nucleophilic substitution reactions, coupling reactions, and as a building block for heterocyclic synthesis. Store under inert conditions at 2-8°C to maintain stability. Available in research (1g, 5g, 10g) and bulk quantities (100g, 1kg) with customizable packaging.

Properties

• CAS Number: 62257-16-3
• Complexity: 99.1
• IUPAC Name: 3-amino-4-fluoro-phenol
• InChI: InChI=1S/C6H6FNO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H,8H2
• InChI Key: VJCSFNNTQGRAKH-UHFFFAOYSA-N
• Exact Mass: 127.043341977
• Molecular Formula: C6H6FNO
• Molecular Weight: 127.12
• SMILES: C1=CC(=C(C=C1O)N)F
• Topological: 46.3
• Monoisotopic Mass: 127.043341977
• Synonyms: 3-Amino-4-fluorophenol, 62257-16-3, DTXSID20542795, DTXCID70493581, 690-814-8, 3-amino-4-fluoro-phenol, MFCD09033850, Phenol, 3-amino-4-fluoro-, 2-Fluoro-5-hydroxyaniline, SCHEMBL533939, VJCSFNNTQGRAKH-UHFFFAOYSA-N, BCP26806, AC-885, SBB069836, AKOS005063864, CS-W007503, FA42957, PS-9171, SY022950, EN300-117280, F2108-0123, Z1201624911

Application

3-Amino-4-fluorophenol serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, including kinase inhibitors and antimicrobial agents. Its reactive amino and hydroxyl groups enable facile derivatization for specialty chemicals and dyes. Researchers utilize it in Suzuki-Miyaura cross-coupling reactions to construct biaryl scaffolds for drug discovery. Also employed in material science for developing fluorinated polymers with enhanced thermal stability.

Safety and Hazards

GHS Hazard Statements

• H302+H312+H332 (85.7%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H315 (90.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (90.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (90.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (90.5%)
• Eye Irrit. 2A (90.5%)
• STOT SE 3 (90.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.