Description

(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride (CAS No. 848133-35-7) is a high-purity organic compound with the molecular formula C₆H₁₂ClNO₂. This hydrochloride salt of (E)-4-(dimethylamino)but-2-enoic acid is a white to off-white crystalline powder, ideal for research and pharmaceutical applications. It is characterized by its unsaturated carboxylic acid structure with a dimethylamino substituent, offering reactivity useful in synthetic organic chemistry. The compound is supplied with comprehensive analytical data, including HPLC, NMR, and MS for quality assurance. Store in a cool, dry place, protected from light and moisture to ensure stability.

Properties

• CAS Number: 848133-35-7
• Complexity: 118
• IUPAC Name: (E)-4-(dimethylamino)but-2-enoic acid;hydrochloride
• InChI: InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+;
• InChI Key: UUHNQHFOIVLAQX-BJILWQEISA-N
• Exact Mass: 165.0556563
• Molecular Formula: C6H12ClNO2
• Molecular Weight: 165.62
• SMILES: CN(C)C/C=C/C(=O)O.Cl
• Topological: 40.5
• Monoisotopic Mass: 165.0556563
• Synonyms: (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride, 4-(Dimethylamino)-2-butenoic acid hydrochloride, ZRA8B68TND, 2-Butenoic acid, 4-(dimethylamino)-, hydrochloride, (2E)-, (2e)-4-(dimethylamino)-2-butenoic acid hydrochloride, 2-Butenoic acid, 4-(dimethylamino)-, hydrochloride (1:1), (2E)-, 617-631-8, 619-362-1, 848133-35-7, trans-4-Dimethylaminocrotonic acid hydrochloride, 98548-81-3, (E)-4-(Dimethylamino)But-2-Enoic Acid Hydrochloride, 4-(dimethylamino)but-2-enoic acid hydrochloride, 1130155-48-4, (E)-4-(Dimethylamino)but-2-enoic acid xhydrochloride, trans 4-Dimethylaminocrotonic Acid Hydrochloride, UNII-ZRA8B68TND, (E)-4-(dimethylamino)-2-butenoic acid hydrochloride, (E)-4-(dimethylamino)but-2-enoic acid;hydrochloride, Trans-4-dimethylaminocrotonic acid, HCl, (E)-4-(dimethylamino)but-2-enoic acid (Hydrochloride), trans-4-Dimethylaminocrotonic acid HCl, MFCD03695466, trans4-DimethylaminocrotonicAcid-d6Hydrochloride, 98% (only trans), SCHEMBL665365, UUHNQHFOIVLAQX-BJILWQEISA-N, DTXSID101347107, BCP05598, AC-358, AKOS015846406, trans 4-Dimethylaminocrotonic acid HCl, FD22343, SS-4328, 4-dimethylaminocrotonic acid hydrochloride, AS-75535, trans-4-(Dimethylamino)crotonic acid HCl, DB-007927, CS-0132058, D5625, EN300-74132, EN300-736086, A1-03193, (E)-4-(dimethylamino) but-2-enoic acid hydrochloride, 4-(Dimethylamino)-2-butenoic acid hydrochloride, 97%, (2E)-4-(Dimethylamino)but-2-enoic acid hydrogenchloride, (E)-4-(dimethylamino)but-2-enoic acid hydrochloric acid, Z1259335877, (e)-4-(dimethylamino)-2-butenoic acid hydrochloride salt, (E)-4-(dimethylamino)but-2-enoic acid hydrochloride salt, (E)-4-(Dimethylamino)but-2-enoic acid HCl;(E)-4-(Dimethylamino)-2-butenoic acid HCl, (E)-4-(Dimethylamino)but-2-enoic Acid Hydrochloride; (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride;

Application

(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride is widely used as a versatile intermediate in organic synthesis, particularly in the preparation of bioactive molecules and pharmaceuticals. Its reactive α,β-unsaturated carbonyl system makes it valuable for Michael additions and other conjugate addition reactions. Researchers also employ it in the study of enzyme inhibitors and receptor modulators due to its structural similarity to natural amino acid derivatives.

Safety and Hazards

GHS Hazard Statements

• H314 (57.1%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (42.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (14.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (42.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (28.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (57.1%)
• Skin Irrit. 2 (42.9%)
• Eye Dam. 1 (14.3%)
• Eye Irrit. 2 (42.9%)
• STOT SE 3 (28.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.