Description

2,6-Difluorophenol (CAS No. 28177-48-2) is a high-purity fluorinated phenolic compound with the molecular formula C₆H₄F₂O. This aromatic derivative features two fluorine atoms at the ortho positions of the phenol ring, enhancing its reactivity and utility in advanced synthetic applications. Ideal for researchers and industrial chemists, our 2,6-Difluorophenol is rigorously tested to ensure ≥98% purity (GC), making it suitable for pharmaceutical intermediates, agrochemical synthesis, and material science research. The compound is supplied in sealed, light-resistant containers to maintain stability and prevent degradation. Available in quantities ranging from grams to kilograms, it is a versatile building block for nucleophilic aromatic substitution and cross-coupling reactions.

Properties

• CAS Number: 28177-48-2
• Complexity: 87.1
• IUPAC Name: 2,6-difluorophenol
• InChI: InChI=1S/C6H4F2O/c7-4-2-1-3-5(8)6(4)9/h1-3,9H
• InChI Key: CKKOVFGIBXCEIJ-UHFFFAOYSA-N
• Exact Mass: 130.02302107
• Molecular Formula: C6H4F2O
• Molecular Weight: 130.09
• SMILES: C1=CC(=C(C(=C1)F)O)F
• Topological: 20.2
• Monoisotopic Mass: 130.02302107
• Synonyms: 2,6-Difluorophenol, 28177-48-2, Phenol, 2,6-difluoro-, EINECS 248-884-9, CKKOVFGIBXCEIJ-UHFFFAOYSA-, DTXSID00182456, DTXCID10104947, 248-884-9, ckkovfgibxceij-uhfffaoysa-n, inchi=1/c6h4f2o/c7-4-2-1-3-5(8)6(4)9/h1-3,9h, 2,6-Difluoro-phenol, MFCD00002158, 2.6-difluorophenol, 2,6-difluoro phenol, FFP, SCHEMBL9271, 2,6-Difluorophenol, 98%, SCHEMBL331592, SCHEMBL1035467, SCHEMBL9993295, CHEMBL1232721, BCP26982, CL9191, SBB085757, AKOS005259844, AC-3787, CS-W013440, PS-9147, BP-21484, DB-023869, D2015, NS00049957, EN300-22910, Q27460275, Z147646794

Application

2,6-Difluorophenol is widely used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of active pharmaceutical ingredients (APIs) with fluorinated aromatic motifs. It serves as a precursor in agrochemical production, enabling the creation of herbicides and pesticides with enhanced efficacy. Additionally, this compound is employed in material science for designing advanced polymers and liquid crystals due to its unique electronic properties imparted by the fluorine substituents.

Safety and Hazards

GHS Hazard Statements

• H228 (98%): Flammable solid [Danger Flammable solids]
• H302 (16.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (14.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (10.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (89.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (87.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (87.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P240, P241, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P405, and P501

Hazard Classes and Categories

• Flam. Sol. 1 (98%)
• Acute Tox. 4 (16.3%)
• Acute Tox. 4 (14.3%)
• Skin Corr. 1B (10.2%)
• Skin Irrit. 2 (89.8%)
• Eye Irrit. 2 (87.8%)
• STOT SE 3 (87.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.