Description

2,6-Difluoroaniline (CAS No. 5509-65-9) is a high-purity fluorinated aromatic amine with the molecular formula C₆H₅F₂N. This compound is a valuable intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. Its structure features two fluorine atoms at the ortho positions of the aniline ring, enhancing its reactivity and utility in cross-coupling reactions, nucleophilic substitutions, and as a precursor for heterocyclic compounds. Available in liquid form with a purity of ≥98%, our 2,6-Difluoroaniline is rigorously tested via GC, NMR, and HPLC to ensure consistency and reliability for research and industrial applications. Proper handling under inert conditions is recommended due to its sensitivity to air and moisture.

Properties

• CAS Number: 5509-65-9
• Complexity: 87.1
• IUPAC Name: 2,6-difluoroaniline
• InChI: InChI=1S/C6H5F2N/c7-4-2-1-3-5(8)6(4)9/h1-3H,9H2
• InChI Key: ODUZJBKKYBQIBX-UHFFFAOYSA-N
• Exact Mass: 129.03900549
• Molecular Formula: C6H5F2N
• Molecular Weight: 129.11
• SMILES: C1=CC(=C(C(=C1)F)N)F
• Topological: 26
• Monoisotopic Mass: 129.03900549
• Synonyms: 2,6-Difluoroaniline, 5509-65-9, Benzenamine, 2,6-difluoro-, 2,6-DIFLUOROBENZENAMINE, EINECS 226-853-0, NSC 127234, NSC-127234, 943G3H8895, DTXSID2073350, DTXCID7041835, 226-853-0, inchi=1/c6h5f2n/c7-4-2-1-3-5(8)6(4)9/h1-3h,9h, oduzjbkkybqibx-uhfffaoysa-n, 2,6-Difluoro-phenylamine, MFCD00007655, 2,6-Difluorobenzenamine; 2,6-Difluorobenzeneamine; 2,6-Difluorophenylamine; NSC 127234;, NSC127234, 2,6 difluoroaniline, 2,6-diflouroaniline, 2,6-difluoro aniline, 2,6-difluoro-aniline, 2,6-di-Fluoroaniline, 2,6-difluorophenylamine, 2,6-difluorobenzeneamine, 2,6-difluorophenyl amine, (2,6-difluorophenyl)amine, SCHEMBL113475, SCHEMBL3032482, SCHEMBL5508791, SCHEMBL29199639, 2,6-Difluoroaniline, >=97%, UNII-943G3H8895, BBL027652, MSK406022, SBB028233, STK802226, AKOS000119497, CS-W020001, FD39040, PS-9157, DB-027682, D1635, NS00043705, EN300-19913, A19486, F0001-1445, Z104476070

Application

2,6-Difluoroaniline is widely used as a key building block in the synthesis of pharmaceuticals, including active pharmaceutical ingredients (APIs) and agrochemicals. It serves as a precursor for the preparation of herbicides, fungicides, and other fluorinated aromatic compounds. Additionally, this compound is employed in material science for the development of advanced polymers and liquid crystals. Its reactivity makes it suitable for palladium-catalyzed cross-coupling reactions, such as Buchwald-Hartwig amination.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (97.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (57.1%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H312 (41.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H317 (94%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H318 (53.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H331 (57.1%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H332 (41.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H351 (53.4%): Suspected of causing cancer [Warning Carcinogenicity]
• H372 (12%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P333+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Acute Tox. 4 (97.7%)
• Acute Tox. 3 (57.1%)
• Acute Tox. 4 (41.4%)
• Skin Sens. 1B (94%)
• Eye Dam. 1 (53.4%)
• Acute Tox. 3 (57.1%)
• Acute Tox. 4 (41.4%)
• Carc. 2 (53.4%)
• STOT RE 1 (12%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.