Description

2,6-Dibromo-4-fluoroaniline (CAS No. 344-18-3) is a high-purity halogenated aniline derivative with the molecular formula C₆H₄Br₂FN. This compound is characterized by its two bromine substituents at the 2- and 6-positions and a fluorine atom at the 4-position of the aniline ring, making it a valuable intermediate in organic synthesis and pharmaceutical research. With a molecular weight of 268.91 g/mol, it is supplied as a crystalline solid with exceptional purity (>98%) to ensure consistency in sensitive applications. Ideal for use in Suzuki coupling, Buchwald-Hartwig amination, and other cross-coupling reactions, this reagent is rigorously tested for impurities (GC, HPLC) and packaged under inert conditions to guarantee stability. Suitable for researchers in medicinal chemistry, agrochemical development, and materials science.

Properties

• CAS Number: 344-18-3
• Complexity: 110
• IUPAC Name: 2,6-dibromo-4-fluoro-aniline
• InChI: InChI=1S/C6H4Br2FN/c7-4-1-3(9)2-5(8)6(4)10/h1-2H,10H2
• InChI Key: VHPLZFGCNLDYQH-UHFFFAOYSA-N
• Exact Mass: 268.86740
• Molecular Formula: C6H4Br2FN
• Molecular Weight: 268.91
• SMILES: C1=C(C=C(C(=C1Br)N)Br)F
• Topological: 26
• Monoisotopic Mass: 266.86945
• Synonyms: 2,6-Dibromo-4-fluoroaniline, 344-18-3, DTXSID40287631, DTXCID90238779, 608-987-5, inchi=1/c6h4br2fn/c7-4-1-3(9)2-5(8)6(4)10/h1-2h,10h, vhplzfgcnldyqh-uhfffaoysa-n, 1-amino-2,6-dibromo-4-fluorobenzene, Benzenamine, 2,6-dibromo-4-fluoro-, 2,6-dibromo-4-fluoro-aniline, NSC51868, MFCD00041445, 2,6-dibromo-4-flouroaniline, SCHEMBL1192854, 2,6-dibromo-4-fluorophenylamine, 2,6-dibromo-4-fluoro-phenylamine, BCP23140, NSC-51868, STL185562, 2,6-Dibromo-4-fluoroaniline, 98%, AKOS000120587, AC-3673, CS-W010104, AS-12300, DB-002124, D2570, NS00125969, ST50319394, EN300-21061, A19754, Z104487474

Application

2,6-Dibromo-4-fluoroaniline serves as a key building block in the synthesis of fluorinated aromatic compounds, particularly in pharmaceutical and agrochemical research. It is widely used in palladium-catalyzed cross-coupling reactions to introduce bromine and fluorine functionalities into complex molecules. This compound is also employed in the development of liquid crystals and advanced materials due to its stable halogenated structure.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (97.8%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.