Description

2,6-Bis(trifluoromethyl)pyridine (CAS No. 455-00-5) is a high-purity fluorinated pyridine derivative with the molecular formula C₇H₃F₆N. This specialized compound features two trifluoromethyl groups at the 2- and 6-positions of the pyridine ring, enhancing its electron-withdrawing properties and chemical stability. Ideal for advanced research applications, it is rigorously tested to meet stringent quality standards (≥98% purity by GC) and is available in sealed packaging under inert gas to ensure longevity. Suitable for use as a ligand precursor, pharmaceutical intermediate, or agrochemical building block, this product is packaged in amber glass vials or bulk quantities with customizable options. Handle with appropriate PPE due to potential reactivity.

Properties

• CAS Number: 455-00-5
• Complexity: 175
• IUPAC Name: 2,6-bis(trifluoromethyl)pyridine
• InChI: InChI=1S/C7H3F6N/c8-6(9,10)4-2-1-3-5(14-4)7(11,12)13/h1-3H
• InChI Key: YPDVFTXBESQIPJ-UHFFFAOYSA-N
• Exact Mass: 215.01696807
• Molecular Formula: C7H3F6N
• Molecular Weight: 215.10
• SMILES: C1=CC(=NC(=C1)C(F)(F)F)C(F)(F)F
• Topological: 12.9
• Monoisotopic Mass: 215.01696807
• Synonyms: 2,6-Bis(trifluoromethyl)pyridine, 455-00-5, Pyridine, 2,6-bis(trifluoromethyl)-, DTXSID10343470, DTXCID60294549, 622-745-6, ypdvftxbesqipj-uhfffaoysa-n, MFCD00236675, SCHEMBL1804366, SCHEMBL2120639, SCHEMBL3295150, SCHEMBL9901629, BBL104112, SBB095067, STL557927, AKOS005063453, PS-7940, 2,6-Bis(trifluoromethyl)pyridine, 97%, AC-28579, DB-020143, B2395, CS-0046035, ST50827440

Application

2,6-Bis(trifluoromethyl)pyridine serves as a key intermediate in the synthesis of fluorinated ligands for transition metal catalysis, particularly in asymmetric reactions. Its electron-deficient pyridine core is valuable in designing agrochemicals and pharmaceuticals with enhanced metabolic stability. Researchers also utilize it to develop novel materials, such as liquid crystals or polymers, where fluorine substitution modulates electronic properties.

Safety and Hazards

GHS Hazard Statements

• H228 (95.2%): Flammable solid [Danger Flammable solids]
• H301 (95.2%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P240, P241, P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P405, and P501

Hazard Classes and Categories

• Flam. Sol. 2 (95.2%)
• Acute Tox. 3 (95.2%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.