Description

2,5-Difluoropyridine (CAS No. 84476-99-3) is a high-purity fluorinated pyridine derivative with the molecular formula C₅H₃F₂N. This heterocyclic compound is widely utilized in pharmaceutical, agrochemical, and material science research due to its unique reactivity and stability. With a purity of 97%, it serves as a versatile building block for synthesizing complex molecules, including active pharmaceutical ingredients (APIs) and specialty chemicals. Its fluorine substitution pattern enhances electron-withdrawing properties, making it ideal for nucleophilic aromatic substitution reactions and cross-coupling methodologies. Available in sealed packaging under inert conditions, our 2,5-Difluoropyridine ensures consistent quality for demanding laboratory and industrial applications.

Properties

• CAS Number: 84476-99-3
• Complexity: 76.8
• IUPAC Name: 2,5-difluoropyridine
• InChI: InChI=1S/C5H3F2N/c6-4-1-2-5(7)8-3-4/h1-3H
• InChI Key: XFAMUOYNXFXQTC-UHFFFAOYSA-N
• Exact Mass: 115.02335542
• Molecular Formula: C5H3F2N
• Molecular Weight: 115.08
• SMILES: C1=CC(=NC=C1F)F
• Topological: 12.9
• Monoisotopic Mass: 115.02335542
• Synonyms: 2,5-Difluoropyridine, 84476-99-3, DTXSID30376528, DTXCID90327556, 674-957-3, MFCD04114191, Pyridine, 2,5-difluoro-, 2,5-bis(fluoranyl)pyridine, 2,5-Difluoropyridine, 97%, SCHEMBL404295, SCHEMBL406724, SCHEMBL406830, SCHEMBL415945, XFAMUOYNXFXQTC-UHFFFAOYSA-N, 2,5-Difluoropyridine, AldrichCPR, BBL100955, STL554749, AKOS005063482, AC-6251, CS-W003160, FD38498, PS-9232, SY005276, DB-005872, D4174, EN300-98298, A840800

2,5-Difluoropyridine is a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of kinase inhibitors and antiviral agents. Its reactivity enables efficient derivatization for agrochemical applications, such as pesticide and herbicide formulations. Additionally, it serves as a precursor for advanced materials, including liquid crystals and electronic chemicals, due to its stable aromatic core and fluorine substituents.

Safety and Hazards

GHS Hazard Statements

• H226 (95.7%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (97.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (95.7%)
• Skin Irrit. 2 (97.8%)
• Eye Irrit. 2A (97.8%)
• STOT SE 3 (95.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.