Description

Description

2,5-Difluorobenzyl Chloride (CAS No. 495-07-8) is a high-purity organic compound with the molecular formula C₇H₅ClF₂. This versatile reagent is widely used in pharmaceutical and agrochemical synthesis due to its reactive benzylic chloride group and strategically placed fluorine substituents. The compound is supplied as a clear to pale yellow liquid with a characteristic aromatic odor, typically at ??97% purity (GC).

Our 2,5-Difluorobenzyl Chloride is rigorously tested for identity, purity, and stability, making it ideal for nucleophilic substitution reactions, cross-coupling chemistry, and as a building block for advanced intermediates. The product is packaged under inert gas in amber glass bottles to ensure maximum shelf life and is available in research (5g, 25g) and bulk quantities (100g, 1kg).

Key specifications include: Molecular Weight: 162.56 g/mol, Density: 1.28 g/cm³, Boiling Point: 185-187??C, Refractive Index: n_D²⁰ 1.495-1.505. Store at 2-8??C in a well-ventilated area, protected from moisture.

Application

2,5-Difluorobenzyl Chloride serves as a key intermediate in the synthesis of biologically active molecules, particularly in pharmaceutical research where its difluorinated aromatic ring enhances metabolic stability. The compound is frequently employed in Suzuki-Miyaura cross-coupling reactions to create novel biphenyl derivatives for drug discovery. Its reactive chloromethyl group makes it valuable for constructing heterocyclic scaffolds in medicinal chemistry programs targeting CNS and anti-inflammatory therapies.

If you are interested or have any questions, please contact us at support@atomfair.com