Description

2,5-Difluorobenzyl alcohol (CAS No. 75853-20-2) is a high-purity fluorinated aromatic alcohol with the molecular formula C₇H₆F₂O and IUPAC name (2,5-difluorophenyl)methanol. This compound is a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical research, due to its reactive benzyl alcohol group and electron-withdrawing fluorine substituents. It is supplied as a clear, colorless to pale-yellow liquid with ≥98% purity (GC), ensuring optimal performance in coupling reactions, esterifications, and as a precursor for heterocyclic compounds. Suitable for use under inert conditions, this product is rigorously tested for stability, moisture content, and heavy metal residues. Packaged in amber glass bottles under nitrogen to prevent degradation, it is ideal for researchers requiring precise fluorinated intermediates.

Properties

• CAS Number: 75853-20-2
• Complexity: 108
• IUPAC Name: (2,5-difluorophenyl)methanol
• InChI: InChI=1S/C7H6F2O/c8-6-1-2-7(9)5(3-6)4-10/h1-3,10H,4H2
• InChI Key: KIKCAPPVFQLOIU-UHFFFAOYSA-N
• Exact Mass: 144.03867113
• Molecular Formula: C7H6F2O
• Molecular Weight: 144.12
• SMILES: C1=CC(=C(C=C1F)CO)F
• Topological: 20.2
• Monoisotopic Mass: 144.03867113
• Synonyms: 2,5-Difluorobenzyl alcohol, 75853-20-2, (2,5-difluorophenyl)methanol, Benzenemethanol, 2,5-difluoro-, 4L8M6A2PTJ, EINECS 278-325-4, DTXSID20226760, 2,5-DIFLUOROBENZENEMETHANOL, DTXCID50149251, 278-325-4, 2,5-difluorobenzylalcohol, (2,5-difluorophenyl)methan-1-ol, MFCD00010627, UNII-4L8M6A2PTJ, SCHEMBL109397, SCHEMBL1076615, SCHEMBL16962237, (2,5-difluoro-phenyl)-methanol, 2,5-Difluorobenzyl alcohol, 99%, CK2478, SBB064049, AKOS009159518, AC-9734, PS-8983, SB83858, DB-001209, D2818, NS00059819, ST50823887, EN300-1263178, F8882-0637, InChI=1/C7H6F2O/c8-6-1-2-7(9)5(3-6)4-10/h1-3,10H,4H

Application

2,5-Difluorobenzyl alcohol is widely used as a key intermediate in the synthesis of bioactive molecules, including pharmaceuticals and agrochemicals. Its fluorinated aromatic structure enhances metabolic stability and binding affinity in drug discovery, making it valuable for kinase inhibitors and CNS-targeting compounds. Additionally, it serves as a precursor for advanced materials and liquid crystals due to its unique electronic properties.

Safety and Hazards

GHS Hazard Statements

• H315 (15.2%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (84.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (15.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (10.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (15.2%)
• Eye Dam. 1 (84.8%)
• Eye Irrit. 2 (15.2%)
• STOT SE 3 (10.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.