Description

2,5-Difluorobenzenesulfonyl chloride (CAS No. 26120-86-5) is a highly specialized sulfonyl chloride derivative with the molecular formula C₆H₃ClF₂O₂S. This compound is widely utilized in organic synthesis and pharmaceutical research due to its reactive sulfonyl chloride functional group, which facilitates sulfonamide and sulfonate ester formation. With a purity of ≥97%, this reagent is ideal for precision applications in medicinal chemistry, agrochemical development, and material science. Its unique 2,5-difluoro substitution pattern enhances its utility in designing fluorinated bioactive molecules. Packaged under inert conditions to ensure stability, this product is a must-have for researchers seeking high-quality building blocks for complex chemical transformations.

Properties

• CAS Number: 26120-86-5
• Complexity: 249
• IUPAC Name: 2,5-difluorobenzenesulfonyl chloride
• InChI: InChI=1S/C6H3ClF2O2S/c7-12(10,11)6-3-4(8)1-2-5(6)9/h1-3H
• InChI Key: CELLJWUVMKEJDY-UHFFFAOYSA-N
• Exact Mass: 211.9510345
• Molecular Formula: C6H3ClF2O2S
• Molecular Weight: 212.60
• SMILES: C1=CC(=C(C=C1F)S(=O)(=O)Cl)F
• Topological: 42.5
• Monoisotopic Mass: 211.9510345
• Synonyms: 2,5-Difluorobenzenesulfonyl chloride, 26120-86-5, 2,5-Difluorobenzene-1-Sulfonyl Chloride, DTXSID10371697, DTXCID20322731, 607-866-4, Benzenesulfonyl chloride, 2,5-difluoro-, 2,5-Difluorobenzenesulphonyl chloride, 2,5-difluoro-benzenesulfonyl chloride, 2,5-Difluorobenzenesulphonylchloride, MFCD00060682, SCHEMBL574988, (2,5-difluorophenyl)chlorosulfone, 2,5-difluorobenzensulfonylchloride, 2,5-difluorobenzensulfonyl chloride, ALBB-000989, BBL013793, SBB066477, STK500489, 2,5-difluorobenzene sulfonyl chloride, AKOS000123014, CS-W010484, 2,5-Difluorobenzene-1-SulfonylChloride, PS-10900, 2,5-Difluorobenzenesulfonyl chloride, 97%, DB-005870, NS00120657, EN300-12390, F1967-0685

2,5-Difluorobenzenesulfonyl chloride serves as a key intermediate in the synthesis of sulfonamide-based pharmaceuticals and agrochemicals. It is commonly employed in nucleophilic substitution reactions to introduce sulfonyl groups into target molecules. Researchers also use it to develop fluorinated analogs for drug discovery and PET tracer synthesis. Its stability under anhydrous conditions makes it suitable for sensitive reactions.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (84.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)
• Eye Dam. 1 (84.8%)

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