Description

2,5-Dibromo-3-nitropyridine (CAS No. 15862-37-0) is a high-purity halogenated nitropyridine compound with the molecular formula C₅H₂Br₂N₂O₂. This heterocyclic aromatic compound is widely utilized as a versatile intermediate in organic synthesis, pharmaceutical research, and agrochemical development. Its unique structure, featuring bromine substituents at the 2- and 5-positions and a nitro group at the 3-position, enables selective functionalization for complex molecule construction. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a crystalline solid with excellent batch-to-batch consistency. Proper storage under inert atmosphere at 2-8°C is recommended to maintain stability. Suitable for use in cross-coupling reactions, nucleophilic substitutions, and as a precursor for pyridine-based scaffolds. Available in research quantities from milligrams to kilogram scale with full analytical documentation (NMR, MS, HPLC).

Properties

• CAS Number: 15862-37-0
• Complexity: 161
• IUPAC Name: 2,5-dibromo-3-nitro-pyridine
• InChI: InChI=1S/C5H2Br2N2O2/c6-3-1-4(9(10)11)5(7)8-2-3/h1-2H
• InChI Key: OQKWPJCAKRVADO-UHFFFAOYSA-N
• Exact Mass: 281.84625
• Molecular Formula: C5H2Br2N2O2
• Molecular Weight: 281.89
• SMILES: C1=C(C=NC(=C1[N+](=O)[O-])Br)Br
• Topological: 58.7
• Monoisotopic Mass: 279.84830
• Synonyms: 2,5-Dibromo-3-nitropyridine, 15862-37-0, DTXSID20305387, DTXCID70256517, 808-084-8, 2,5-Dibromo-3-nitro-pyridine, PYRIDINE, 2,5-DIBROMO-3-NITRO-, MFCD09266223, NSC170627, SCHEMBL202290, OQKWPJCAKRVADO-UHFFFAOYSA-N, BCP22083, BBL100791, SBB065287, STL554585, 2 pound not5-dibromo-3-nitropyridine, AKOS005255313, CS-W003617, DS-0464, NSC 170627, NSC-170627, PB16150, SB10155, AC-23053, BP-11623, FD142602, SY014308, 2,5-Dibromo-3-nitro-pyridine, AldrichCPR, DB-000130, D4702, EN300-108015

Application

2,5-Dibromo-3-nitropyridine serves as a key building block in medicinal chemistry for the synthesis of pyridine-containing drug candidates. The compound is particularly valuable in palladium-catalyzed cross-coupling reactions for introducing nitropyridine moieties into complex molecules. Researchers utilize this intermediate in the development of kinase inhibitors and other biologically active compounds. In material science, it finds application as a precursor for functionalized pyridine derivatives used in ligand design and coordination chemistry.

Safety and Hazards

GHS Hazard Statements

• H301 (33.3%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (33.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (33.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (33.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (33.3%)
• Acute Tox. 4 (33.3%)
• Acute Tox. 4 (33.3%)
• Skin Irrit. 2 (66.7%)
• Eye Irrit. 2A (66.7%)
• Acute Tox. 4 (33.3%)
• STOT SE 3 (33.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.