Description

Description

2,5-Dibromo-3-fluoropyridine (CAS No. 156772-60-0) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₂Br₂FN. This compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring bromine and fluorine substituents on the pyridine ring, enables selective functionalization for the development of complex heterocyclic systems. Available in >95% purity (HPLC), it is supplied as a white to off-white crystalline solid with strict quality control to ensure batch-to-batch consistency. Ideal for cross-coupling reactions (e.g., Suzuki, Stille), nucleophilic substitutions, and as a precursor for fluorinated bioactive molecules. Packaged under inert gas in amber glass vials to ensure stability. MSDS and analytical certificates available upon request.

Application

2,5-Dibromo-3-fluoropyridine serves as a versatile intermediate in medicinal chemistry for the synthesis of fluorinated drug candidates, particularly kinase inhibitors and CNS-targeting compounds. Its dibromo functionality allows sequential palladium-catalyzed couplings to construct biaryl systems, while the fluorine atom enhances metabolic stability in lead optimization. Researchers also utilize it in material science to develop fluorinated ligands for catalytic systems or luminescent materials. The compound’s reactivity is exploited in agrochemical research for creating novel pyridine-based pesticides.

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