Description

2,5-bis(2,2,2-trifluoroethoxy)benzoic Acid (CAS No. 35480-52-5) is a high-purity fluorinated benzoic acid derivative with the molecular formula C₁₁H₈F₆O₄. This compound features two trifluoroethoxy substituents at the 2- and 5-positions of the benzoic acid ring, enhancing its electron-withdrawing properties and chemical stability. Ideal for pharmaceutical research, organic synthesis, and material science applications, this product is rigorously tested to meet stringent quality standards. Available in various quantities, it is supplied with comprehensive analytical data (including HPLC, NMR, and MS) to ensure reproducibility and reliability in your experiments. Store in a cool, dry place under inert conditions to maintain optimal stability.

Properties

• CAS Number: 35480-52-5
• Complexity: 354
• IUPAC Name: 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid
• InChI: InChI=1S/C11H8F6O4/c12-10(13,14)4-20-6-1-2-8(7(3-6)9(18)19)21-5-11(15,16)17/h1-3H,4-5H2,(H,18,19)
• InChI Key: YPGYLCZBZKRYQJ-UHFFFAOYSA-N
• Exact Mass: 318.03267770
• Molecular Formula: C11H8F6O4
• Molecular Weight: 318.17
• SMILES: C1=CC(=C(C=C1OCC(F)(F)F)C(=O)O)OCC(F)(F)F
• Topological: 55.8
• Monoisotopic Mass: 318.03267770
• Synonyms: 2,5-bis(2,2,2-trifluoroethoxy)benzoic Acid, 35480-52-5, BENZOIC ACID, 2,5-BIS(2,2,2-TRIFLUOROETHOXY)-, ID4JP01L3W, FLECAINIDE ACID, UNII-ID4JP01L3W, DTXSID50371111, EC 609-132-9, FLECAINIDE ACID [USP IMPURITY], FLECAINIDE ACID (USP IMPURITY), DTXCID70322145, 609-132-9, 2,5-bis(trifluoroethoxy)benzoic acid, MFCD00221424, 2,5-Bis(2,2,2-trifluoroethoxy)benzoicAcid-d3, Flecainide Acetate Imp. D (EP); 2,5-Bis(2,2,2-trifluoroethoxy)benzoic Acid; Flecainide Acetate Impurity D; Flecainide Impurity D, 2,5-Bis(2,2,2-trifluoroethoxy)benzoicAcid, Flecainide acetate impurity D, SCHEMBL978291, CS-M0605, SBB064413, AKOS015852999, AC-3902, FB18650, PS-7060, PD065532, SY017998, DB-020015, 2,5-bis(2,2,2-trifluorethoxy)benzoic acid, B3227, NS00003212, ST51007130, 2,5-di-(2,2,2-trifluoroethoxy)benzoic acid, EN300-76845, 2,5-bis (2,2,2-trifluoroethoxy)benzoic acid, FLECAINIDE ACETATE IMPURITY D [EP IMPURITY], 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid, AldrichCPR, Z1190330980

Application

2,5-bis(2,2,2-trifluoroethoxy)benzoic Acid is a key intermediate in the synthesis of flecainide and other antiarrhythmic drugs. Its fluorinated structure makes it valuable in medicinal chemistry for modifying pharmacokinetic properties. Researchers also utilize it as a building block for advanced materials with unique electronic or hydrophobic characteristics. Its electron-deficient aromatic core is useful in ligand design for catalysis.

Safety and Hazards

GHS Hazard Statements

• H315 (93%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (93%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (90.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (93%)
• Eye Irrit. 2 (93%)
• STOT SE 3 (90.7%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.