Description

2,4,5-Trifluoroaniline (CAS No. 367-34-0) is a high-purity fluorinated aromatic amine with the molecular formula C₆H₄F₃N. This compound is a valuable intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. Its trifluorinated structure enhances reactivity and stability, making it ideal for nucleophilic substitution reactions and cross-coupling methodologies. Available in >98% purity (GC), this product is rigorously tested for consistency, ensuring optimal performance in research and industrial applications. Packaged under inert gas to prevent degradation, it is supplied in amber glass vials or bulk quantities with customizable options.

Properties

• CAS Number: 367-34-0
• Complexity: 120
• IUPAC Name: 2,4,5-trifluoroaniline
• InChI: InChI=1S/C6H4F3N/c7-3-1-5(9)6(10)2-4(3)8/h1-2H,10H2
• InChI Key: QMYVWJVVVMIBMM-UHFFFAOYSA-N
• Exact Mass: 147.02958362
• Molecular Formula: C6H4F3N
• Molecular Weight: 147.10
• SMILES: C1=C(C(=CC(=C1F)F)F)N
• Topological: 26
• Monoisotopic Mass: 147.02958362
• Synonyms: 2,4,5-Trifluoroaniline, 367-34-0, Benzenamine, 2,4,5-trifluoro-, EINECS 206-692-2, AI3-52252, QMYVWJVVVMIBMM-UHFFFAOYSA-, DTXSID50190147, NSC 10289, DTXCID60112638, 206-692-2, inchi=1/c6h4f3n/c7-3-1-5(9)6(10)2-4(3)8/h1-2h,10h2, qmyvwjvvvmibmm-uhfffaoysa-n, 2,4,5-trifluorophenylamine, 84X2Y688WR, NSC-10289, 2,4,5-trifluorobenzenamine, NSC10289, MFCD00007649, 2,4,5-triflouroaniline, 2,4,5-trifloro aniline, 2,4,5-trifluoro-aniline, SCHEMBL11695, 2,4,5-Trifluoro-phenylamine, Aniline, 2,4,5-trifluoro-, UNII-84X2Y688WR, SCHEMBL2998055, SCHEMBL27982044, 2,4,5-Trifluoroaniline, 99%, STR06087, SBB028281, STL195581, TD1278, AKOS006221646, AC-3745, CS-W005036, FT64358, DB-023942, NS00041713, ST50824055, T1645, EN300-65646, A19847, Z1021287670, Benzenamine, 2,4,5-trifluoro-;2,4,5-trifluorobenzenamine

Application

2,4,5-Trifluoroaniline is widely used as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. Its electron-deficient aromatic ring facilitates the introduction of additional functional groups via palladium-catalyzed reactions. Researchers also employ it in the development of liquid crystals and advanced materials due to its fluorine-mediated polarity. In medicinal chemistry, it serves as a precursor for fluorinated analogs of bioactive molecules.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (87%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (87%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.