Description

2,4-Difluorotoluene (CAS No. 452-76-6) is a high-purity fluorinated aromatic compound with the molecular formula C₇H₆F₂ and IUPAC name 2,4-difluoro-1-methylbenzene. This colorless to pale-yellow liquid is characterized by its low viscosity and distinctive aromatic odor. With a boiling point of approximately 120-122°C and density of ~1.16 g/mL at 25°C, it offers excellent solubility in common organic solvents while being immiscible with water. The electron-withdrawing fluorine substituents make this compound particularly valuable as a building block in pharmaceutical synthesis, agrochemical production, and advanced material science. Our product is rigorously tested to meet >98% purity standards (GC) and is supplied in amber glass bottles or specialized fluoropolymer-lined containers to ensure stability. Technical data including NMR spectra, GC-MS analysis, and safety documentation are available upon request.

Properties

• CAS Number: 452-76-6
• Complexity: 92.9
• IUPAC Name: 2,4-difluoro-1-methyl-benzene
• InChI: InChI=1S/C7H6F2/c1-5-2-3-6(8)4-7(5)9/h2-4H,1H3
• InChI Key: MPXDAIBTYWGBSL-UHFFFAOYSA-N
• Exact Mass: 128.04375652
• Molecular Formula: C7H6F2
• Molecular Weight: 128.12
• SMILES: CC1=C(C=C(C=C1)F)F
• Monoisotopic Mass: 128.04375652
• Physical Description: Colorless liquid with an aromatic odor;
• Synonyms: 2,4-Difluorotoluene, 2,4-Difluoro-1-methylbenzene, Difluorotoluene, Benzene, 2,4-difluoro-1-methyl-, RMK2YU8CT4, NSC-3465, EINECS 207-211-9, MPXDAIBTYWGBSL-UHFFFAOYSA-, DTXSID70196429, TOLUENE, 2,4-DIFLUORO-, NSC 3465, 2F-toluene, 2,4Difluorotoluene, DTXCID30118920, 207-211-9, inchi=1/c7h6f2/c1-5-2-3-6(8)4-7(5)9/h2-4h,1h3, mpxdaibtywgbsl-uhfffaoysa-n, 452-76-6, 2,4-difluoro-toluene, UNII-RMK2YU8CT4, SCHEMBL60954, SCHEMBL96362, SCHEMBL99060, 2,4-Difluorotoluene, 99%, SCHEMBL129103, SCHEMBL972121, Benzene,4-difluoro-1-methyl-, SCHEMBL2344889, SCHEMBL19614371, SCHEMBL27956750, NSC3465, 2,4-Difluoro-1-methylbenzene #, MFCD00000332, SBB085715, AKOS005063642, AC-9822, CS-W011136, FD64657, AS-33273, BP-11380, DB-000363, A7140, D2351, NS00043468, EN300-95446, Q63409741

Application

2,4-Difluorotoluene serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly protease inhibitors and antifungal agents. In material science, it’s employed as a precursor for liquid crystal monomers and dielectric fluids for advanced electronics. The compound’s unique electronic properties make it valuable for developing agrochemicals with enhanced bioavailability and environmental stability.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)

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