Description

2,4-Difluoronitrobenzene (CAS No. 446-35-5) is a high-purity aromatic compound with the molecular formula C₆H₃F₂NO₂. This yellow crystalline solid is a valuable intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty materials. Its IUPAC name is 2,4-difluoro-1-nitrobenzene, and it features two fluorine atoms at the 2- and 4-positions of the benzene ring, along with a nitro group at the 1-position. The compound is known for its reactivity in nucleophilic aromatic substitution (S_NAr) reactions, making it a versatile building block for heterocyclic chemistry. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed containers to maintain stability. Suitable for research, process development, and industrial applications.

Properties

• CAS Number: 446-35-5
• Complexity: 159
• IUPAC Name: 2,4-difluoro-1-nitro-benzene
• InChI: InChI=1S/C6H3F2NO2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H
• InChI Key: RJXOVESYJFXCGI-UHFFFAOYSA-N
• Exact Mass: 159.01318466
• Molecular Formula: C6H3F2NO2
• Molecular Weight: 159.09
• SMILES: C1=CC(=C(C=C1F)F)[N+](=O)[O-]
• Topological: 45.8
• Monoisotopic Mass: 159.01318466
• Synonyms: 2,4-Difluoronitrobenzene, 446-35-5, 2,4-Difluoro-1-nitrobenzene, 1-Nitro-2,4-difluorobenzene, 1,3-Difluoro-4-nitrobenzene, Benzene, 2,4-difluoro-1-nitro-, EINECS 207-167-0, NSC 10259, BRN 2048034, DTXSID0032869, 6398Y1D7JS, NSC-10259, DTXCID8012869, RJXOVESYJFXCGI-UHFFFAOYSA-, 1,5-DIFLUORO-2-NITROBENZENEE, 207-167-0, inchi=1/c6h3f2no2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3h, 2,4-Difluoro-1-nitro-benzene, MFCD00007050, MLS001055483, SMR001227187, UNII-6398Y1D7JS, 2,4-difluornitrobenzol, 2,4-difluoronitrobenzol, 2,4-difluor-nitrobenzene, 2,4-di-fluoronitrobenzene, 2,4-difluoro-nitrobenzene, 2,4-difluoronitro-benzene, 2,4-difluoro-nitro-benzene, 1,3-Difluor-4-nitrobenzol, SCHEMBL57112, cid_67967, Benzene,4-difluoro-1-nitro-, CHEMBL31425, 2,4-difluor-1-nitro-benzene, SCHEMBL1531096, SCHEMBL9263394, SCHEMBL17347338, SCHEMBL29241423, 2,4-Difluoronitrobenzene, 99%, BDBM74207, NSC10259, Tox21_200688, SBB063035, 2,4-bis(fluoranyl)-1-nitro-benzene, AKOS009031333, CS-W020034, FD64613, NCGC00090989-01, NCGC00090989-02, NCGC00090989-03, NCGC00258242-01, AC-10690, AS-13424, CAS-446-35-5, DB-024041, D1636, NS00043428, ST51039921, EN300-21357, 1,3-Difluoro-4-nitrobenzene;2,4-Difluoronitrobenzene, Q27263583, Z104495524

Application

2,4-Difluoronitrobenzene is widely used as a precursor in the synthesis of fluorinated anilines, benzimidazoles, and other nitrogen-containing heterocycles. It serves as a key intermediate in the production of pharmaceuticals, including antifungal and antibacterial agents. Additionally, this compound is employed in agrochemical research for developing novel pesticides and herbicides. Its reactivity in S_NAr reactions allows for selective functionalization, enabling the creation of complex molecular architectures.

Safety and Hazards

GHS Hazard Statements

• H227: Combustible liquid [Warning Flammable liquids]
• H301: Toxic if swallowed [Danger Acute toxicity, oral]
• H310: Fatal in contact with skin [Danger Acute toxicity, dermal]
• H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]
• H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]
• H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P210, P260, P262, P264, P270, P273, P280, P301+P316, P302+P352, P308+P316, P316, P321, P330, P361+P364, P370+P378, P391, P403, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (100%)
• Acute Tox. 3 (12%)
• Skin Irrit. 2 (94%)
• Eye Irrit. 2 (96%)
• Acute Tox. 2 (10%)
• STOT SE 3 (92%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.