Description

2,4-Difluorobenzoyl chloride (CAS No. 72482-64-5) is a high-purity fluorinated benzoyl chloride derivative with the molecular formula C₇H₃ClF₂O. This reactive organofluorine compound is widely utilized in pharmaceutical, agrochemical, and materials science research due to its role as a versatile acylating agent. The presence of fluorine atoms at the 2- and 4-positions of the aromatic ring enhances its electron-withdrawing properties, making it particularly valuable for synthesizing fluorinated intermediates. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in moisture-free packaging to prevent hydrolysis. Suitable for Schotten-Baumann reactions, Friedel-Crafts acylation, and peptide coupling, this compound is a critical building block for advanced heterocyclic chemistry.

Properties

• CAS Number: 72482-64-5
• Complexity: 163
• IUPAC Name: 2,4-difluorobenzoyl chloride
• InChI: InChI=1S/C7H3ClF2O/c8-7(11)5-2-1-4(9)3-6(5)10/h1-3H
• InChI Key: JSWRVDNTKPAJLB-UHFFFAOYSA-N
• Exact Mass: 175.9840487
• Molecular Formula: C7H3ClF2O
• Molecular Weight: 176.55
• SMILES: C1=CC(=C(C=C1F)F)C(=O)Cl
• Topological: 17.1
• Monoisotopic Mass: 175.9840487
• Synonyms: 2,4-Difluorobenzoyl chloride, 72482-64-5, Benzoyl chloride, 2,4-difluoro-, 77DL5FRC0Z, 2,4-difluorobenzoic acid chloride, EINECS 276-690-4, JSWRVDNTKPAJLB-UHFFFAOYSA-, DTXSID30222778, 2,4-DIFLUOROBENZOYL CHLORIDE ACID CHLORIDE, DTXCID60145269, 276-690-4, inchi=1/c7h3clf2o/c8-7(11)5-2-1-4(9)3-6(5)10/h1-3h, jswrvdntkpajlb-uhfffaoysa-n, 2,4-difluorobenzoylchloride, MFCD00000658, 2,4difluorobenzoylchloride, UNII-77DL5FRC0Z, 2,4-difluorobezoyl chloride, 2,4 difluorobenzoyl chloride, 2,4-difluoro benzoylchloride, 2,4-difluoro-benzoylchloride, SCHEMBL165619, 2,4-Difluoro-benzoyl chloride, 2,4-Difluorobenzoyl chloride, 98%, SBB006623, alpha-chloro-2,4-difluorobenzaldehyde, AKOS007930879, 2,4-difluoro-1-benzenecarbonyl chloride, PS-10781, DB-019934, D1882, NS00063745, ST51039981, EN300-156036, F2190-0142

Application

2,4-Difluorobenzoyl chloride is primarily used as a key intermediate in the synthesis of fluorinated pharmaceuticals, including antifungal and CNS-active compounds. It serves as an acylating agent in the preparation of amides, esters, and ketones with enhanced metabolic stability due to fluorine substitution. Researchers also employ this compound in materials science to modify polymer backbones or create fluorinated liquid crystals with unique dielectric properties.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (39%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (90.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)
• Eye Dam. 1 (39%)
• STOT SE 3 (90.9%)

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