Description

2,4-Difluoroanisole (CAS No. 452-10-8) is a high-purity fluorinated aromatic compound with the molecular formula C₇H₆F₂O. This specialty chemical is widely utilized in pharmaceutical synthesis, agrochemical development, and advanced material research due to its unique electronic and steric properties. As a versatile building block, it features a methoxy group adjacent to two fluorine atoms on the benzene ring, enabling selective reactivity in coupling reactions, nucleophilic substitutions, and as a precursor for complex fluorinated scaffolds. Our product is rigorously tested to ensure ≥98% purity (GC), with stringent quality control for trace solvents and heavy metals, making it ideal for sensitive applications. Available in research quantities (1g to 1kg) with custom packaging options, it is supplied with comprehensive analytical documentation (HPLC, NMR, MS).

Properties

• CAS Number: 452-10-8
• Complexity: 108
• IUPAC Name: 2,4-difluoro-1-methoxy-benzene
• InChI: InChI=1S/C7H6F2O/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,1H3
• InChI Key: CRMJLJFDPNJIQA-UHFFFAOYSA-N
• Exact Mass: 144.03867113
• Molecular Formula: C7H6F2O
• Molecular Weight: 144.12
• SMILES: COC1=C(C=C(C=C1)F)F
• Topological: 9.2
• Monoisotopic Mass: 144.03867113
• Synonyms: 2,4-Difluoroanisole, 452-10-8, 2,4-Difluoro-1-methoxybenzene, DTXSID60196418, DTXCID70118909, 610-230-9, 252-10-8, Benzene, 2,4-difluoro-1-methoxy-, MFCD00010731, SCHEMBL197204, 1,3-Difluoro-4-methoxybenzene, SCHEMBL1068238, SCHEMBL1205136, SCHEMBL1547178, SCHEMBL2351921, 2,4-Difluoro-1-methoxybenzene #, SBB086326, AKOS005255195, AC-3784, CS-W011011, PS-8980, DB-024053, 1H,5H-Pyrazolo[1,2-a]pyrazole(8ci,9ci), D1849, NS00120801, ST50823884, A19863, EN300-102841, H10488, 2,4-Difluoro-1-methoxybenzene; 2,4-Difluoroanisole, InChI=1/C7H6F2O/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,1H

2,4-Difluoroanisole serves as a key intermediate in the synthesis of bioactive molecules, particularly in the development of fluorinated pharmaceuticals and crop protection agents. Its electron-deficient aromatic ring facilitates palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura) for constructing biaryl systems. Researchers employ this compound to introduce fluorine motifs that enhance metabolic stability in drug discovery. It also finds use in liquid crystal and OLED material development due to its polarity and conformational rigidity.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (71.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (71.4%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.