Description

Description

2,4-Difluoro-5-iodobenzoic acid (CAS No. 161531-51-7) is a high-purity halogenated benzoic acid derivative with the molecular formula C₇H₃F₂IO₂. This compound features a benzoic acid core substituted with two fluorine atoms at the 2- and 4-positions and an iodine atom at the 5-position, making it a versatile intermediate for synthetic organic chemistry and pharmaceutical research. Its unique structure enables selective reactivity in cross-coupling reactions, nucleophilic substitutions, and metal-catalyzed transformations.

Our product is rigorously tested for purity (typically ??95% by HPLC or GC analysis) and is supplied as a crystalline solid with excellent shelf stability. Ideal for researchers developing fluorinated aromatic compounds, PET radiotracers, or bioactive molecules, this compound is packaged under inert conditions to ensure longevity and performance consistency. Available in quantities from milligrams to kilograms, with custom synthesis options upon request.

Application

2,4-Difluoro-5-iodobenzoic acid serves as a key building block in medicinal chemistry for the synthesis of fluorinated drug candidates, particularly in oncology and CNS therapeutics. Its iodine moiety facilitates Suzuki-Miyaura or Sonogashira cross-coupling reactions to introduce complex aryl/alkyne groups. The difluoro substitution enhances metabolic stability in bioactive molecules. Researchers also utilize it to prepare iodine-labeled probes for imaging studies or as a precursor for radiopharmaceuticals.

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