Atomfair 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine C6H3Cl2N3 CAS 90213-66-4

Description

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (CAS No. 90213-66-4) is a high-purity heterocyclic compound with the molecular formula C₆H₃Cl₂N₃. This versatile building block is widely used in pharmaceutical research, particularly in the synthesis of kinase inhibitors and other bioactive molecules. Its unique pyrrolopyrimidine scaffold makes it an essential intermediate for medicinal chemistry applications.

Our product is rigorously tested to ensure >98% purity (HPLC) and is supplied as a fine white to off-white crystalline powder. It is packaged under inert conditions to ensure stability and long shelf life. Ideal for high-throughput screening, lead optimization, and process development in drug discovery.

Key Features:
– High chemical purity
– Batch-specific Certificate of Analysis
– Suitable for nucleophilic substitution reactions
– Stable under recommended storage conditions (2-8°C)
– Available in research quantities from milligrams to kilograms

Properties

• CAS Number: 90213-66-4
• Complexity: 155
• IUPAC Name: 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine
• InChI: InChI=1S/C6H3Cl2N3/c7-4-3-1-2-9-5(3)11-6(8)10-4/h1-2H,(H,9,10,11)
• InChI Key: GHXBPCSSQOKKGB-UHFFFAOYSA-N
• Exact Mass: 186.9704025
• Molecular Formula: C6H3Cl2N3
• Molecular Weight: 188.01
• SMILES: C1=CNC2=C1C(=NC(=N2)Cl)Cl
• Topological: 41.6
• Monoisotopic Mass: 186.9704025
• Synonyms: 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, 90213-66-4, DTXSID80556131, 2,4-Dichloro-7H-pyrrolo(2,3-d)pyrimidine, DTXCID80506914, 618-507-6, 2,4-dichloro-1H-pyrrolo[2,3-d]pyrimidine, 2,6-Dichloro-7-deazapurine, 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE, 2,4-Dichloro-7H-pyrrolo (2,3-d)pyrimidine, MFCD08059278, Tofacitinib Impurity 08, 2,4-dichloropyrrolo[2,3-d]pyrimidine, 1H-Pyrrolo[2,3-d]pyrimidine, 2,4-dichloro-, 2,4-dichloro-7h-pyrrolo[2,3-d] pyrimidine, A2NE6H5F6Q, SCHEMBL352433, SCHEMBL691603, 7H-PYRROLO[2,3-D]PYRIMIDINE, 2,4-DICHLORO-, GHXBPCSSQOKKGB-UHFFFAOYSA-N, BCP00152, CS-B0455, BBL103561, CL3495, SBB054735, STL557371, AKOS005256964, AKOS015907660, AC-4446, FD09691, GS-6918, PB30992, PS-5648, HY-40350, SY003887, 7H-2,4-dichloro-pyrrolo[2,3-d]pyrimidine, DB-031958, D4284, 2,4-di chloro-7H-pyrrolo[2,3-d]pyrimidine, EN300-109601, 2,4-bis(chloranyl)-7H-pyrrolo[2,3-d]pyrimidine, A843469, A1-00635, 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, AldrichCPR, Z1741972597

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine serves as a key synthetic intermediate for Janus kinase (JAK) inhibitors including tofacitinib analogs. The dichloro substitution pattern allows selective functionalization at either the 2- or 4-position through stepwise nucleophilic aromatic substitution. This compound has demonstrated particular utility in the development of immunomodulatory agents and anticancer therapeutics targeting signaling pathways.

Safety and Hazards

GHS Hazard Statements

• H301 (14.3%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (57.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (85.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (85.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (71.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (14.3%)
• Acute Tox. 4 (57.1%)
• Skin Irrit. 2 (85.7%)
• Eye Irrit. 2 (85.7%)
• STOT SE 3 (71.4%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.